Journal Article10.1165/RCMB.2002-0166TR
Matrix metalloproteinase-9 in lung remodeling.
TL;DR: The current understanding of MMP-9 in human asthma, IPF, and COPD, and in animal models of these conditions is addressed.
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Abstract: Matrix metalloproteinase (MMP)-9 (Gelatinase B, 92-kD type IV collagenase, EC 3.4.24.35) is an MMP that is present in low quantities in the healthy adult lung, but much more abundant in several lung diseases, including asthma, idiopathic pulmonary fibrosis (IPF), and chronic obstructive pulmonary disease (COPD). Despite numerous reports of MMP-9 in these and other lung diseases, whether MMP-9 is causal in lung remodeling or part of the inflammatory and reparative response remains to be determined. Many intrinsic lung cells can be stimulated to produce MMP-9, but much of the information regarding MMP-9 in the lung deals with MMP-9 from inflammatory cells. The multiple locations and cell types producing MMP-9 are consistent with multiple functions in different microenvironments. In addition to digestion of structural proteins and antiproteases, MMP-9 can modify cellular function by regulation of cytokines and matrix-bound growth factors. Determining the role of MMP-9 in health and disease will be important,...
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Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen)
Jean Bousquet,N. Khaltaev,Alvaro A. Cruz,Judah A. Denburg,W. J. Fokkens,Alkis Togias,T. Zuberbier,Carlos E. Baena-Cagnani,Giorgio Walter Canonica,C. van Weel,Ioana Agache,Nadia Aït-Khaled,Claus Bachert,Michael S. Blaiss,Sergio Bonini,L.-P. Boulet,Philippe-Jean Bousquet,Paulo Augusto Moreira Camargos,K-H. Carlsen,Y. Z. Chen,Adnan Custovic,Ronald Dahl,Pascal Demoly,H. Douagui,Stephen R. Durham,R. Gerth van Wijk,O. Kalayci,Michael A. Kaliner,You Young Kim,Marek L. Kowalski,Piotr Kuna,L. T. T. Le,Catherine Lemière,Jing Li,Richard F. Lockey,S. Mavale-Manuel,Eli O. Meltzer,Y. Mohammad,J Mullol,Robert M. Naclerio,Robyn E O'Hehir,K. Ohta,S. Ouedraogo,S. Palkonen,Nikolaos G. Papadopoulos,Gianni Passalacqua,Ruby Pawankar,Todor A. Popov,Klaus F. Rabe,J Rosado-Pinto,G. K. Scadding,F. E. R. Simons,Elina Toskala,E. Valovirta,P. Van Cauwenberge,De Yun Wang,Magnus Wickman,Barbara P. Yawn,Arzu Yorgancioglu,Osman M. Yusuf,H. J. Zar,Isabella Annesi-Maesano,E.D. Bateman,A. Ben Kheder,Daniel A. Boakye,J. Bouchard,Peter Burney,William W. Busse,Moira Chan-Yeung,Niels H. Chavannes,A.G. Chuchalin,William K. Dolen,R. Emuzyte,Lawrence Grouse,Marc Humbert,C. M. Jackson,Sebastian L. Johnston,Paul K. Keith,James P. Kemp,J. M. Klossek,Désirée Larenas-Linnemann,Brian J. Lipworth,Jean-Luc Malo,Gailen D. Marshall,Charles K. Naspitz,K. Nekam,Bodo Niggemann,Ewa Nizankowska-Mogilnicka,Yoshitaka Okamoto,M. P. Orru,Paul Potter,David Price,Stuart W. Stoloff,Olivier Vandenplas,Giovanni Viegi,Dennis M. Williams +95 more
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Jean Bousquet,N. Khaltaev,A. A. Cruz,Judah A. Denburg,W. J. Fokkens,Alkis Togias,T. Zuberbier,Carlos E. Baena-Cagnani,G.W. Canonica,C. van Weel,Ioana Agache,Nadia Aït-Khaled,Claus Bachert,Blaiss,Sergio Bonini,L.P. Boulet,P. J. Bousquet,P. Camargos,K-H. Carlsen,Yijing Chen,Adnan Custovic,Ronald Dahl,Pascal Demoly,H. Douagui,Stephen R. Durham,R.G. van Wijk,O. Kalayci,Kaliner,Y.Y. Kim,Marek L. Kowalski,Piotr Kuna,L.T. Le,Catherine Lemière,J. Li,R. F. Lockey,S. Mavale-Manuel,E. O. Meltzer,Yousser Mohammad,J Mullol,D.A. Boakye +39 more
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TL;DR: The Zar Review Group: I.J. Bousquet, N. Khaltaev, A. R. Rabe, J. Rosado-Pinto, G. Scadding, F. Simons, E. Togias, T. Valovirta, P. Vandenplas, D. Wang, M. Stoloff, O. Williams.
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Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 Revision
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TL;DR: These are the most recent and currently the most systematically and transparently developed recommendations about the treatment of allergic rhinitis in adults and children and patients are encouraged to use these recommendations in their daily practice and to support their decisions.
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Asthma: Mechanisms of Disease Persistence and Progression
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References
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Expression of matrix metalloproteinase-2 and -9 during early human wound healing
TL;DR: During wound healing, MMP-9 is suggested to be involved in keratinocyte migration and granulation tissue remodelling by in situ hybridization, which means that expression of M MP-2 remains stable during wound healing.
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases define the migratory characteristics of human monocyte‐derived dendritic cells
TL;DR: The data indicate that MMP and TIMP play a role in the migratory ability of human DCs, and suggest that TIMP‐3 expression might represent a new marker of maturation ofhuman DCs.
Bronchial subepithelial fibrosis and expression of matrix metalloproteinase-9 in asthmatic airway inflammation
TL;DR: It is suggested that collagen III, collagen V, and tenascin deposition in basement membrane in subjects with bronchial asthma are associated with increased expression of MMP-9, which may be produced by eosinophils, and that airway remodeling in Subjects with asthma may be related to air-flow obstruction and airway hyperresponsiveness.
SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages.
Scott M. Wilhelm,Ivan E. Collier,Barry L. Marmer,Arthur Z. Eisen,Gregory A. Grant,Gregory I. Goldberg +5 more
TL;DR: The complete structure of this enzyme is presented along with the evidence that it is identical to the 92-kDa metalloprotease secreted by normal human alveolar macrophages, phorbol ester-differentiated monocytic leukemia U937 cells, fibrosarcoma HT1080 cells, and cultured human keratinocytes.
The Structural Basis for the Elastolytic Activity of the 92-kDa and 72-kDa Gelatinases ROLE OF THE FIBRONECTIN TYPE II-LIKE REPEATS
J. Michael Shipley,Glenn A. R. Doyle,Catherine J. Fliszar,Ye Qi-Zhuang,Johnson Linda Lea,Steven D. Shapiro,Howard G. Welgus,Robert M. Senior +7 more
TL;DR: In this article, the role of fibronectin type II-like repeats in elastolytic activity of matrix metalloproteinases (MME and matrilysin) was investigated.