Maternal thyroid hypofunction and pregnancy outcome.
Jane Cleary-Goldman,Fergal D. Malone,Geralyn Lambert-Messerlian,Lisa M. Sullivan,Jacob A. Canick,T. Flint Porter,David A. Luthy,Susan J. Gross,Diana W. Bianchi,Mary E. D'Alton +9 more
514
TL;DR: Maternal thyroid hypofunction is not associated with a consistent pattern of adverse outcomes, and there was an increased risk for preterm premature rupture of membranes when both antibodies were positive in either trimester.
read more
About: This article is published in Obstetrics & Gynecology. The article was published on 01 Jul 2008. and is currently open access. The article focuses on the topics: Thyroid disease in pregnancy & Thyroid peroxidase.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Early Maternal Thyroid Function During Gestation Is Associated With Fetal Growth, Particularly in Male Newborns.
TL;DR: Maternal fT4 in early pregnancy was observed to be inversely associated with birth weight, with a stronger relationship in males, and sexual dimorphism appears to be present in the relationship between maternal thyroid metabolism and fetal intrauterine growth, with stronger associations in male infants.
79
Clinical Parameters Are More Likely to Be Associated with Thyroid Hormone Levels than with Thyrotropin Levels: A Systematic Review and Meta-Analysis
TL;DR: Thyroid hormones levels, and in particular fT4 levels, seem to have stronger associations with clinical parameters than do TSH levels, which warrants reconsideration.
77
Impaired Fertility Associated with Subclinical Hypothyroidism and Thyroid Autoimmunity: The Danish General Suburban Population Study.
Anne-Dorthe Feldthusen,Palle Pedersen,Jacob Larsen,Tina Toft Kristensen,Christina Ellervik,Jan Kvetny +5 more
TL;DR: Impaired fertility is associated with TSH, TPOAb, and mild (subclinical) hypothyroidism in a Danish population of women.
MANAGEMENT OF ENDOCRINE DISEASE: Isolated maternal hypothyroxinemia during pregnancy: Knowns and unknowns
Chrysoula Dosiou,Marco Medici +1 more
TL;DR: The significance of IMH based on data from animal models and recent discoveries regarding the role of thyroid hormone on neurodevelopment are discussed and the need for a sufficiently powered, placebo-controlled RCT on the treatment ofIMH early in the first trimester of pregnancy is emphasized.
Maternal thyroid peroxidase antibodies during pregnancy: A marker of impaired child development?
TL;DR: It is concluded that children of pregnant women who had elevated titers of TPO-Ab but normal thyroid function are at risk for impaired development.
72
References
Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child.
James E. Haddow,Glenn E. Palomaki,Walter C. Allan,Josephine Williams,George J. Knight,June Gagnon,Cheryl E. O’heir,Marvin L. Mitchell,Rosalie J. Hermos,Susan E. Waisbren,James D. Faix,Robert Z. Klein +11 more
TL;DR: Undiagnosed hypothyroidism in pregnant women may adversely affect their fetuses; therefore, screening for thyroid deficiency during pregnancy may be warranted.
2.4K
Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy
Victor J M Pop,J.L. Kuijpens,van Baar Al,Gerda J. M. Verkerk,van Son Mm,de Vijlder Jj,Thomas Vulsma,Wilmar M. Wiersinga,Hemmo A. Drexhage,H L Vader +9 more
TL;DR: Maternal thyroid function during early pregnancy is an important determinant of early fetal brain development because the fetal thyroid is unable to produce any T4 before 12–14 weeks' gestation.
1K
First-trimester or second-trimester screening, or both, for down's syndrome
Fergal D. Malone,Fergal D. Malone,Fergal D. Malone,Jacob A. Canick,Robert H. Ball,David A. Nyberg,Christine H. Comstock,Radek Bukowski,Richard L. Berkowitz,Susan J. Gross,Lorraine Dugoff,Sabrina D. Craigo,Ilan E. Timor-Tritsch,Stephen R. Carr,Honor M. Wolfe,Kimberly A. Dukes,Diana W. Bianchi,Alicja R. Rudnicka,A. K. Hackshaw,A. K. Hackshaw,Geralyn Lambert-Messerlian,Nicholas J. Wald,Mary E. D'Alton +22 more
TL;DR: First-trimester combined screening at 11 weeks of gestation is better than secondtrimester quadruple screening but at 13 weeks has results similar to second-tr pregnancy quadruple screened, except for the comparison between serum integrated screening and combined screening.
Subclinical hypothyroidism and pregnancy outcomes.
Brian M. Casey,Jodi S. Dashe,C. Edward Wells,Donald D. McIntire,William Byrd,Kenneth J. Leveno,F. Gary Cunningham +6 more
TL;DR: It is speculated that the previously reported reduction in intelligence quotient of offspring of women with subclinical hypothyroidism may be related to the effects of prematurity.
968
First-Trimester or Second-Trimester Screening, or Both, for Down???s Syndrome
Fergal D. Malone,Jacob A. Canick,Robert H. Ball,David A. Nyberg,Christine H. Comstock,Radek Bukowski,Richard L. Berkowitz,Susan J. Gross,Lorraine Dugoff,Sabrina D. Craigo,Ilan E. Timor-Tritsch,Stephen R. Carr,Honor M. Wolfe,Kimberly A. Dukes,Diana W. Bianchi,Alicja R. Rudnicka,A. K. Hackshaw,Geralyn Lambert-Messerlian,Nicholas J. Wald,Mary E. D'Alton +19 more
TL;DR: First-trimester combined screening at 11 weeks of gestation is better than second- Trimester quadruple screening but at 13 weeks has results similar to second- trimester quadruples screening.