Mass spectrometry of some arylidene thioxobenzyl or thioxobiphenyloxoethyl thiazolidinone compounds
Vera Lúcia de Miranda Guarda,C. Bosso,Suely Lins Galdino,J. F. C. Albuquerque,M. C. A. Lima,João Bosco P. da Silva,Lucia Fernanda C. C. Leite,Ivan da Rocha Pitta +7 more
TL;DR: In this article, a comparative study of the electron impact mass spectrometry data for a series of previously synthetized 5-arylidene-3-(4-chloro-benzyl)-4-thioxo-thiazolidin-2-one derivatives was performed.
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Abstract: This paper reports the results of a comparative study of the electron impact mass spectrometry data for a series of previously synthetized 5-arylidene-3-(4-chloro-benzyl)-4-thioxo-thiazolidin-2-one, and 5-arylidene-3-(2-biphenyl-4-yl-2-oxo- ethyl)-4-thioxo-thiazolidin-2-one derivatives. Theoretical calculations of molecular mechanics, MOPAC-AM1, were used to explain the fragmentations observed.
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Citations
A simple green synthesis of (Z)-5-arylmethylene-4- thioxothiazolidines and thiopyrano[2,3-d]thiazolidine-2-thiones in PEG-400 under catalyst-free conditions
TL;DR: In this paper, an improved Knoevenagel condensation of various aromatic aldehydes with thiazolidine-2,4-dithione and with 4-thioxothiazolidin-4-one was achieved at room temperature in polyethylene glycol-400 without catalyst to afford (Z)-5-arylmethylene-4 thioxothiaolidine derivatives 3a-3o.
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A Novel Synthesis of 1,4-Bis(thiopyrano[2,3-d]thiazolyl)benzene Derivatives
TL;DR: In this paper, the 5-(4-formylphenyl)methylene-thiazolidine-2,4-dithione derivatives were synthesized by condensation of each of 4-thioxo-thiaolidin-2-one (la) and thiazolidines-2.4dithion with terephthalaldehyde (1b) in good yields depending on the molar ratio of 1 to 2.
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A Convenient Synthesis of Some New 5-Substituted-4-Thioxo-Thiazolidinones and Fused Thiopyrano[2,3-d]thiazole Derivatives
TL;DR: In this paper, the new Z-5-arylmethylene-4-thioxo-thiazolidine derivatives have been synthesized by condensation of ω -(4-formylphenoxy)acetophenone derivatives with 4-thoxylmethylene derivatives, in good yields.
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Synthesis and anticancer activity of some new thiopyrano[2,3-d]thiazoles incorporating pyrazole moiety.
TL;DR: The anticancer activity of some of the newly synthesized compounds was investigated against different human cancer cell lines and confirmed by molecular docking, and the structure for one representative example of the new products was confirmed by X-ray crystallography.
References
Thiazolidinedione derivative improves fat distribution and multiple risk factors in subjects with visceral fat accumulation--double-blind placebo-controlled trial.
Tadashi Nakamura,Tohru Funahashi,Shizuya Yamashita,Makoto Nishida,Yoshiharu Nishida,Masahiko Takahashi,Kikuko Hotta,Hiroshi Kuriyama,Shinji Kihara,Noriyuki Ohuchi,Takamichi Nishimura,Bunichiro Kishino,Katsunori Ishikawa,Toshiharu Kawamoto,Katsuto Tokunaga,Chisa Nakagawa,Ikuo Mineo,Fumiko Watanabe,Seiichiro Tarui,Yuji Matsuzawa +19 more
TL;DR: Thiazolidinedione derivative may be a useful drug to improve multiple risk factors by changing the fat distribution in subjects with visceral fat accumulation by decreasing the ratio of visceral fat area to subcutaneous fat area (VFA) and increased SFA.
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Mechanisms by which Thiazolidinediones Enhance Insulin Action.
TL;DR: Thiazolidinediones are an exciting new class of insulin-sensitizing drugs being used currently for the treatment of non-insulin-dependent diabetes mellitus, yet a major site of TZD-responsive glucose disposal is skeletal muscle, yet PPARgamma is expressed predominantly in adipose tissue.
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