Patent
Mass resolution in time-of-flight mass spectrometers with reflectors
Armin Holle,Claus Koster,Jochen Franzen +2 more
- 04 Apr 1996
56
TL;DR: In this paper, an intermediate time-focus plane for ions of a certain mass at a location between an ion source and an ion reflector is generated for high resolution analysis of analyte ions in a time of flight mass spectrometer.
read more
Abstract: A method for the high resolution analysis of analyte ions in a time-of-flight mass spectrometer. The method consists of the generation of an intermediate time-focus plane for ions of a certain mass at a location between an ion source and an ion reflector, and then using the ion reflector to temporally focus the ions of equal mass and differing velocities which pass this plane at the same time onto a detector. For time-of-flight mass spectrometers with an ion selector, the ion selector is particularly favorable location for this intermediate plane with time focus; and with a collision cell for the collision fragmentation of the ions, the collision cell is a particularly favorable location.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Patent
DNA diagnostics based on mass spectrometry
Hubert Köster
- 18 Mar 1996
TL;DR: In this article, a mass spectrometer-based process for detecting nucleic acid sequences in a biological sample was proposed, which can be used to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.
511
Patent
Method and apparatus for maldi analysis
Franz Hillenkamp,Dirk Reuter,Scott Higgins,David M. Lough +3 more
- 19 Sep 1997
TL;DR: In this paper, a matrix assisted laser desorption/ionization is performed in a manner to thermalize large analyte ions in a plume of desorbed material for spectroscopic analysis.
237
Patent
Infrared matrix-assisted laser desorption/ionization mass spectrometric analysis of macromolecules
Franz Hillenkamp,Hubert Köster +1 more
- 07 May 1999
TL;DR: In this article, a mixture of a biological macromolecule, such as a nucleic acid molecule or a polypeptide, and a liquid matrix, which absorbs infrared (IR) radiation is provided.
218
Patent
Time-of-flight mass spectrometry analysis of biomolecules
Marvin L. Vestal,Peter Juhasz +1 more
- 10 Apr 1998
TL;DR: In this paper, a time-of-flight mass spectrometer for measuring the mass-to-charge ratio of a sample molecule is described, which provides independent control of the electric field experienced by the sample before and during ion extraction.
212
Patent
High density immobilization of nucleic acids
Maryanne J. O'donnell,Charles R. Cantor,Daniel P. Little,Hubert Köster +3 more
- 06 Nov 1997
TL;DR: In this article, the authors present a set of tools for mass spectrometric detection of nucleic acids on an insoluble surface, which can be used for nucleic acid synthesis, hybridization and/or extension, and sequencing.
193
References
Patent
Spatial-velocity correlation focusing in time-of-flight mass spectrometry
James P. Reilly,Steven M. Colby,Timothy B. King +2 more
- 01 Dec 1995
TL;DR: In this article, an apparatus and method for minimizing ion peak width measurements in a time-of-flight mass spectrometer to thereby minimize the effects of initial ion position distributions and initial ion velocity distributions on the mass resolution of the spectrometers are provided.
63
Patent
MS-MS time-of-flight mass spectrometer
Ulrich Dr. Boesl,Edward W. Schlag,K. Walter,Rainer Weinkauf +3 more
- 20 Jun 1990
TL;DR: In this article, the MS-MS time-of-flight mass spectrometer is operated using a reflector comprising a movable reflector end plate with adjustable potential, which enables primary ions to be eliminated from the spectrum without any loss in mass resolution.
55
Converting a reflectron time‐of‐flight mass spectrometer into a tandem instrument
TL;DR: In this article, a new type of mass gate is described that does not have any grids and is especially suitable for cluster studies, and three processes that lead to an undesirable high background in a reflectron time-of-flight mass spectrometer are identified.
32
High-resolution mass spectrometry in a linear time-of-flight mass spectrometer
TL;DR: In this article, the authors describe a new method to achieve high-resolution mass spectra in a linear time-of-flight mass spectrometer using post-source pulse-focusing.
32
Patent
Coaxial thermoelements and thermocouples made from the coaxial thermoelements
Jr. Bertie Forrest Hall
- 15 Jun 1994
TL;DR: In this article, a thermocouple is formed by fusing the wire from a coaxial thermoelement to its metal sheath in each of two thermoelements (10, 10') and joining the fused ends of the two coaxials (10 and 10') to form a thermocalouple junction.
17
Related Papers (5)
Marvin L. Vestal,Peter Juhasz +1 more
- 10 Apr 1998
Hubert Köster,Nanda Dual Sinha +1 more
- 10 Aug 1984
Hubert Köster
- 06 Jan 1994