Patent
Marker for assessing the risk of developing acute kidney injury
Pablo Cardinal Fernández,Antonio Ferruelo,José A. Lorente +2 more
- 11 Oct 2012
1
TL;DR: In this article, the authors provided an in vitro method to determine the risk to develop acute kidney injury (AKI) in a subject, the method comprising the step of detecting the presence of a CC polymorphism at position + 936 of the human vascular endothelial growth factor (VEGF) from an isolated sample of the subject.
read more
Abstract: It is provided an in vitro method to determine the risk to develop acute kidney injury (AKI) in a subject, the method comprising the step of detecting the presence of a CC polymorphism at position +936 of the human vascular endothelial growth factor (VEGF) from an isolated sample of the subject, wherein the presence of said polymorphism indicates the risk to develop AKI. With the method of the invention, a new tool to be used in the clinic is made available, allowing the prognosis of a serious life-threatening complication. Additionally, the use of means for detecting the polymorphism are also claimed.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Patent
Molecular marker, kit and application for use in early diagnosis and prediction of sepsis as complication of acute kidney injury
Dongshan Zhang,Qu Siyuan,Huiling Li,Pan Zhang +3 more
- 22 Nov 2018
TL;DR: In this article, a molecular marker, a kit and an application for use in the early diagnosis and prediction of sepsis as a complication of acute kidney injury is presented, where the expression level of TCONS_00024536 in the blood of a patient is determined by means of detecting whether the patient is suffering from Sepsis or acute kidney infection.
References
BCL2 Genetic Variants Are Associated With Acute Kidney Injury in Septic Shock
Angela J. Frank,Chau-Chyun Sheu,Chau-Chyun Sheu,Yang Zhao,Feng Chen,Li Su,Michelle N. Gong,Ednan K. Bajwa,B. Taylor Thompson,David C. Christiani +9 more
TL;DR: Large-scale genotyping reveals two single nucleotide polymorphisms in the BCL2 gene and a singleucleotide polymorphism in the SERPINA4 gene associated with a decreased risk of developing acute kidney injury, supporting the putative role of apoptosis in the pathogenesis of acute kidneys injury.
VEGF 936 C/T gene polymorphism in renal transplant recipients: association of the T allele with good graft outcome.
Ramazan Gunesacar,Gerhard Opelz,Eren Erken,Steffen Pelzl,Bernd Döhler,Andrea Ruhenstroth,Caner Süsal +6 more
TL;DR: The VEGF 936 CT genotype and T allele appear to be associated with good outcome in renal transplantation and, if confirmed, might be helpful for the pretransplant identification of recipients with low risk of graft rejection.
25
•Journal Article
Cytokine single nucleotide polymorphism. Role in acute renal failure.
TL;DR: Ultimately, cytokine-modulating therapies could be employed on the basis of genotypic risk stratification with the goal to prevent kidney injury or minimize its deleterious effects on patient outcome.
6
Vascular endothelial growth factor gene polymorphisms in North Indian patients with end stage renal disease
TL;DR: The results highlight the role of studied VEGF polymorphisms in end stage renal disease at large and subsequently in the three primary kidney diseases among the North Indian population.