Marine natural products.

TL;DR: Marine molluscs are rich sources of nutraceuticals and medicinal compounds. They contain various bioactive compounds with pharmacological activities such as antimicrobial, anticancer, antioxidant, and anti-inflammatory properties.

TL;DR: This review explores marine natural products' potential in treating inflammation-related diseases, highlighting their diverse structures and bioactivities, and discussing their mechanisms and limitations, with a focus on addressing current challenges in their development and application.

TL;DR: This study reviews 337 natural products from marine-derived Aspergillus species, including 145 new compounds, with diverse structures and antimicrobial activities against pathogenic bacteria, offering potential lead compounds for antimicrobial agent development.

TL;DR: One novel bisabolane-derived sesquiterpenoid retrobisabolane A, featuring a methyl group location at the C-4 position instead of C-3 in the bisabolanes, and a known ester-substituted eremophilane-type sesquiterpenoid cryptosphaerolide, along with three known indole alkaloids were discovered from the fermented cultures of a deep-sea-derived fungus.

TL;DR: A 10-step gram-scale synthesis of 9,11-secosteroid pinnisterol E from the inexpensive ergosterol is reported in this paper , which features a series of highly selective redox transformations such as regioselective olefin hydrogenation (PtO2), acid-sensitive endoperoxide reduction (Al-Ni alloy, Zn), and regio-and diastereose-lective dienone oxidation.

TL;DR: In this article , three new metabolites, including cyclic tetrapeptide asperhiratide (1), an ecdysteroid derivative asperhriratine (2), and a sesquiterpene lactone asperrhiratone (3), were isolated and identified from the soft coral-derived fungus Aspergillus hiratsukae SCSIO 5Bn1003, together with 10 known compounds.

TL;DR: The data suggest that the anaenamide scaffold is tunable to produce differential biological outcomes, and in contrast to cytotoxic methyl esters 1 and 2, the primary amides 3 and 4 activate the Nrf2 pathway at noncytotoxic concentrations.

TL;DR: In this article , 12 new members of the dolabellane family, cooccurring with three related known diterpenoids (13, 14, 15), were isolated from the Xisha soft coral Clavularia viridis.