Marine natural products.

TL;DR: This review of 228 diterpenes from 33 sponge genera (2009-2022) highlights their diverse biological activities, with 110 exhibiting cytotoxic, antibacterial, and anti-inflammatory properties, underscoring marine sponges' potential for new bioactive molecules.

TL;DR: This review summarizes 252 anti-inflammatory compounds from marine microorganisms (2021-2023), predominantly from fungi, highlighting their structures and pharmacological properties as potential lead compounds for clinical applications in human health.

TL;DR: A quantitative examination of the field from the perspective of both number of compounds and compound novelty using a dataset of all published microbial and marine-derived natural products suggests that the development of innovative discovery methods will continue to yield compounds with unique structural and biological properties.

TL;DR: Analysis of molecular descriptors, distribution in chemical space and biological activities of natural products found that natural products have vast chemical diversity, good drug-like properties and can interact with multiple cellular target proteins.

TL;DR: The Natural Products Atlas is designed as a community-supported resource to provide a central repository for known natural product structures from microorganisms and is the first comprehensive, open access resource of this type.

TL;DR: This paper investigated the diversity and novelty of biosynthetic gene clusters in the ocean by integrating around 10,000 microbial genomes from cultivated and single cells with more than 25,000 newly reconstructed draft genomes from more than 1,000 seawater samples.