Mannich type reactions of chlorophosphites, phosphoramides and aldehydes (ketones) under solvent-free and catalyst-free conditions—synthesis of N-phosphoramino α-aminophosphonates

TL;DR: In this paper, the authors summarized the results reported mainly within the last 10 years, and it is quite clear from the growing number of emerging publications in this field that the possibility to utilize multicomponent technology allows reaction conditions to be accessed that are very valuable for organic synthesis.

TL;DR: In this article, an efficient L-proline catalyzed one-pot synthesis of 3-amino-alkylated indoles has been developed via a three-component Mannich-type reaction viz. secondary amines, aldehyde and indoles under solvent-free conditions at room temperature.

TL;DR: A grinding-induced catalyst and solvent-free domino multicomponent reaction for the synthesis of 1,4-dihydropyridines has been developed using aldehydes, amines, DEAD (diethyl acetylenedicarboxylate), and malononitrile/ethyl cyanoacetate as discussed by the authors.

TL;DR: In this article, the carbon-carbon (C-C) bond forms the backbone of nearly every organic molecule and lies at the heart of the chemical sciences, and the most effective way to save energy is to develop strategies/protocols that are capable enough to carry out the transformations at ambient temperature and pressure.

TL;DR: The Mg(ClO4)2-catalyzed alpha-aminophosphonate synthesis in the present study perhaps represents a true three-component reaction as no intermediate formation of either an imine or alpha-hydroxy phosphonate was observed that indicated the simultaneous involvement of the carbonyl compound, the amine, and the phosphite in the transition state.

TL;DR: In this article, a simple, efficient, and general method was developed for the synthesis of α-amino phosphonates through a one-pot reaction of aldehydes and ketones with amines in the presence of indium(III) chloride as a catalyst.

TL;DR: The tripeptide Boc-Val-Pro-ValP(OPh)2, which has a sequence found in a good trifluoromethyl ketone inhibitor of HLE, is the best inhibitor for HLE and porcine pancreatic elastase and the rates of inactivation of chymotrypsin were decreased 2-5-fold in the presence of the corresponding substrate.

TL;DR: TaCl5−SiO2 has been used as an efficient Lewis acid catalyst for the three component coupling of carbonyl compounds, aromatic amines and diethyl phosphite to produce α-amino phosphonates as discussed by the authors.