Journal Article10.1023/A:1020347818725
Mammary gland immunity and mastitis susceptibility.
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TL;DR: This paper provides a comprehensive overview of mammary gland immunity and how the stage of lactation can impact important host defenses and comparisons to humans and other domestic mammals will be addressed.
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Abstract: Lactation is considered the final phase of the mammalian reproductive cycle, and the mammary gland provides milk for nourishment and disease resistance to the newborn. However, the cellular and soluble immune components associated with mammary tissues and secretion also can play an important role in protecting the gland from infectious diseases, such as mastitis. Mastitis can affect essentially all lactating mammals, but is especially problematic for dairy cattle. The most recent estimates from the National Mastitis Council suggest that mastitis affects one third of all dairy cows and will cost the dairy industry over 2 billion dollars annually in the United States in lost profits (National Mastitis Council (1996) Current Concepts in Bovine Mastitis, National Mastitis Council, Madison, WI). The overall impact of mastitis on the quality and quantity of milk produced for human consumption has provided the impetus to better understand the pathophysiology of the mammary gland and develop ways to enhance disease resistance through immunoregulation. As such, the bovine species has played a critical and prominent role in our current understanding of mammary gland immunobiology. This paper provides a comprehensive overview of mammary gland immunity and how the stage of lactation can impact important host defenses. While this review emphasizes the bovine system, comparisons to humans and other domestic mammals will be addressed as well.
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Citations
Bacteriophage endolysins as novel antimicrobials
TL;DR: The modular structure of endolysins is reviewed, in which cell wall binding and catalytic functions are separated, as well as their mechanism of action, lytic activity and potential as antimicrobials.
Severity of E. coli mastitis is mainly determined by cow factors
TL;DR: This review is a compilation of some major findings over the last 15 years concerning mainly host factors that modulate and influence neutrophil function and the mammary inflammatory reaction.
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Innate immunity of the bovine mammary gland
Pascal Rainard,Céline Riollet +1 more
TL;DR: Powerful new research tools are radically modifying the prospects for the understanding of the interplay between the mammary gland innate defenses and mastitis-causing bacteria: genetic dissection of the immune response, microarray gene technology, transcriptomic methodologies and gene silencing by RNA interference will make possible the discovery of several of the key defense mechanisms which govern the susceptibility/resistance to mastitis at the molecular and genetic levels.
Mastitis detection: current trends and future perspectives
TL;DR: Significant advances in the identification of nucleic acid markers and other novel biomarkers and the development of sensor-based platforms have taken place and these novel strategies have shown promise, and their advantages over the conventional tests are discussed.
560
Mammary tissue damage during bovine mastitis: causes and control.
Xin Zhao,Pierre Lacasse +1 more
TL;DR: In vitro and in vivo studies suggest that the use of antioxidants and other protective compounds in mastitis control programs is worth investigating, because they may aid in alleviating damage to secretory cells and thus reduce subsequent milk loss.
510
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•Journal Article
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