Journal Article10.1056/NEJMRA0708126
Malignant Gliomas in Adults
Patrick Y. Wen,Santosh Kesari +1 more
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TL;DR: The authors found that approximately 5% of patients with malignant gliomas have a family history of glioma and most of these familial cases are associated with rare genetic syndromes, such as neurofibromatosis types 1 and 2, the Li−Fraumeni syndrome (germ-line p53 mutations associated with an increased risk of several cancers), and Turcot's syndrome (intestinal polyposis and brain tumors).
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Abstract: Approximately 5% of patients with malignant gliomas have a family history of gliomas. Some of these familial cases are associated with rare genetic syndromes, such as neurofibromatosis types 1 and 2, the Li−Fraumeni syndrome (germ-line p53 mutations associated with an increased risk of several cancers), and Turcot’s syndrome (intestinal polyposis and brain tumors). 10 However, most familial cases have
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ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages
Jinlong Yin,Sung-Soo Kim,Eunji Choi,Young-Taek Oh,Young-Taek Oh,Weiwei Lin,Tae Hoon Kim,Jason K. Sa,Jason K. Sa,Jun Hee Hong,Se Hwan Park,Hyung-Joon Kwon,Xiong Jin,Yeonhee You,Ji Hye Kim,Hyunggee Kim,Jaekyoung Son,Jeongwu Lee,Do-Hyun Nam,Kui Son Choi,Bingyang Shi,Ho Shin Gwak,Heon Yoo,Antonio Iavarone,Jong Heon Kim,Jong Bae Park +25 more
TL;DR: It is demonstrated that ARS2 (arsenite-resistance protein 2), a zinc finger protein that is essential for early mammalian development, plays critical roles in GSC maintenance and M2-like TAM polarization, and a role for the ARs2/MAGL signalling in regulating self-renewal and tumorigenicity of GSCs and M1- like TAM polarization is demonstrated.
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The Coincidence Between Increasing Age, Immunosuppression, and the Incidence of Patients With Glioblastoma.
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Glioma-associated microglial MMP9 expression is upregulated by TLR2 signaling and sensitive to minocycline
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TL;DR: The development of a xenograft assay that identified human brain tumour initiating cells that initiate tumours in vivo gives strong support for the CSC hypothesis as the basis for many solid tumours, and establishes a previously unidentified cellular target for more effective cancer therapies.
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Comprehensive genomic characterization defines human glioblastoma genes and core pathways
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