Making lipids very unhappy to discover how they bind to proteins

TL;DR: A deep residual network for predicting interresidue orientations, in addition to distances, and a Rosetta-constrained energy-minimization protocol for rapidly and accurately generating structure models guided by these restraints are developed.

TL;DR: Understanding of how different lipids achieve their final destination at the molecular level allows a better explanation of the range of defects that occur in diseases associated with lipid transport and distribution, opening up the possibility of developing therapies that specifically target lipid transfer.

TL;DR: The role of non-vesicular lipid transport has been discussed in this article, where a review describes what we know about non-veto lipid transfer mechanisms while also identifying many remaining unknowns: How do LTPs facilitate lipid movement from and into membranes, do LTLTPs require accessory proteins for efficient transfer in vivo, and how is directionality of transport determined?

TL;DR: This work highlights the recently identified chorein_N family of lipid transporters, including the Vps13 proteins and the autophagy protein Atg2, elongated proteins that, distinct from previously characterized transport proteins, bind tens of lipids at once.