Major histocompatibility complex class I-related chain A/B (MICA/B) expression in tumor tissue and serum of pancreatic cancer: Role of uric acid accumulation in gemcitabine-induced MICA/B expression
Xiulong Xu,Geetha Rao,Veronika Groh,Thomas Spies,Paolo Gattuso,Howard L. Kaufman,Janet M. D. Plate,Richard A. Prinz,Richard A. Prinz +8 more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
ALCAM: A Novel Surface Marker on EpCAMlow Circulating Tumor Cells
Rossana Signorelli,Teresa M. Giret,Oliver Umland,M. Hadisurya,Shweta Lavania,John Lalith Charles Richard,Ashley Middleton,M. Boone,Ayse Ergonul,W. Andy Tao,Haleh Amirian,Anton Iliuk,Aliya Khan,Robert Diaz,Daniel B. Cortes,Monica T. Garcia-Buitrago,Harrys Kishore Charles Jacob +16 more
TL;DR: ALCAM was validated and identified as a novel alternate surface marker on EpCAMlow CTCs, which is a novel robust marker in GEMM models and in patient samples.
Association between uric acid, cancer incidence and mortality in patients with type 2 diabetes: Shanghai diabetes registry study.
TL;DR: This study aimed to investigate the association between the serum uric acid, cancer incidence, and mortality in Chinese patients with type 2 diabetes.
A Polynesian-specific copy number variant encompassing the MHC Class I Polypeptide-related Sequence A (MICA) gene associates with gout.
Ke Wang,Murray Cadzow,Matthew J. Bixley,Megan Leask,Marilyn E. Merriman,Qiang Zhen Yang,Zhiqiang Liu,Riku Takei,Amanda Phipps-Green,Tanya J Major,Ruth Topless,Nicola Dalbeth,Frances King,Rinki Murphy,Lisa K. Stamp,Janak de Zoysa,Zhuo Wang,Yongyong Shi,Tony R. Merriman +18 more
TL;DR: Evidence is provided for the association of CNVR1 containing MICA with gout in Polynesian peoples, implicating class I MHC-mediated antigen presentation in gout.
Midkine upregulates MICA/B expression in human gastric cancer cells and decreases natural killer cell cytotoxicity
TL;DR: Overall, the current study shows that MK expression in tumor cells indirectly suppresses NK cytotoxicity by inducing MICA/B expression and suppressing NKG2D expression.
Natural killer cells and their therapeutic role in pancreatic cancer: A systematic review.
Jonas Van Audenaerde,Jonas Van Audenaerde,Geert Roeyen,Phillip K. Darcy,Michael H. Kershaw,Marc Peeters,Evelien Smits +6 more
TL;DR: Although several issues regarding NK cells in Pancreatic cancer remain unsolved and need further investigation, extensive evidence is already provided that support NK cell oriented approaches in pancreatic cancer.
References
Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation
TL;DR: It is shown that binding of MIC induces endocytosis and degradation of NKG2D, a mode of T-cell silencing that may promote tumour immune evasion and, by inference, compromise host resistance to infections.
1.6K
Roles of the NKG2D immunoreceptor and its ligands
TL;DR: This review summarizes recent findings that concern NKG2D, its ligands, its signalling properties and its role in disease, and provides a framework for considering how the induction of immune responses can be regulated by cellular responses to injury.
The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
TL;DR: The DNA damage response, previously shown to arrest the cell cycle and enhance DNA repair functions, or to trigger apoptosis, may also participate in alerting the immune system to the presence of potentially dangerous cells.
Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells
TL;DR: In this paper, the expression and recognition of a major histocompatibility complex (MHC) class I-related molecule, MICA, matches this localization, and the closely related MICB were recognized by intestinal epithelial T cells expressing diverse Vδ1 γδ TCRs.
1.1K