Major histocompatibility complex class I-related chain A/B (MICA/B) expression in tumor tissue and serum of pancreatic cancer: Role of uric acid accumulation in gemcitabine-induced MICA/B expression
Xiulong Xu,Geetha Rao,Veronika Groh,Thomas Spies,Paolo Gattuso,Howard L. Kaufman,Janet M. D. Plate,Richard A. Prinz,Richard A. Prinz +8 more
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Citations
Exploring the causal association between uric acid and lung cancer in east Asian and European populations: a mendelian randomization study
Peter Ping Lin,Linxiang Zhang,Xiaohui Tang,J. Wang +3 more
TL;DR: The results of this study suggested that serum uric acid levels were negatively associated with lung cancer, with uric acid being a potential protective factor for lung cancer.
Patent
Modified a1-a2 domains of non-natural nkg2d ligands that bind non-natural nkg2d receptors
Kim Kaman C,Landgraf Kyle E +1 more
- 03 Oct 2019
TL;DR: In this paper, the production of polypeptides comprised of modified α1-α2 domains of NKG2D ligands which bind specifically to a nonnatural ectodomain of a non-natural NN receptor and wherein heterologous molecules are attached to the modified α 1-α 2 domains of NN ligands, and in some embodiments, antibodies or fragments of antibodies.
Combining Hyperthermia and Immunotherapy: NK Therapy and Hyperthermia
Hiroshi Terunuma,Noriyuki Nishino,Tsuyoshi Abe,Akiko Yoshimura,Atsushi Toki,Tatsuaki Ishiguro,Xuewen Deng,Atsushi Terunuma +7 more
- 01 Jan 2016
TL;DR: Ex vivo-expanded NK cells used in immunotherapy, the effects ofhyperthermia on NK activity, and clinical applications of the combinatory therapy with hyperthermia and NK cells are described.
Stress-induced MICA and MICB molecules in oncology
TL;DR: At the early stage of tumor formation, these proteins contribute to activation ofNK cells and elimination of transformed cells, whereas, at the later stage of this process, the increased production of its soluble forms leads to a decrease in anti-tumor activity of NK cells.
References
Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation
TL;DR: It is shown that binding of MIC induces endocytosis and degradation of NKG2D, a mode of T-cell silencing that may promote tumour immune evasion and, by inference, compromise host resistance to infections.
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Roles of the NKG2D immunoreceptor and its ligands
TL;DR: This review summarizes recent findings that concern NKG2D, its ligands, its signalling properties and its role in disease, and provides a framework for considering how the induction of immune responses can be regulated by cellular responses to injury.
The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
TL;DR: The DNA damage response, previously shown to arrest the cell cycle and enhance DNA repair functions, or to trigger apoptosis, may also participate in alerting the immune system to the presence of potentially dangerous cells.
Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells
TL;DR: In this paper, the expression and recognition of a major histocompatibility complex (MHC) class I-related molecule, MICA, matches this localization, and the closely related MICB were recognized by intestinal epithelial T cells expressing diverse Vδ1 γδ TCRs.
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