Journal Article10.1002/MRM.1910300115
Magnetic resonance-guided thermal surgery
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TL;DR: A demonstration of MR guided thermal surgery involved experiments with imaging of focused ultrasound in an MRI system, measurements of the thermal transients and a thermal analysis of the resulting images, which give an effective thermal diffusion coefficient.
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Abstract: A demonstration of MR guided thermal surgery involved experiments with imaging of focused ultrasound in an MRI system, measurements of the thermal transients and a thermal analysis of the resulting images. Both the heat distribution and the creation of focused ultrasound lesions in gel phantoms, in vitro bovine muscle and in vivo rabbit muscle were monitored with magnetic resonance imaging. Thermal surgical procedures were modeled by an elongated gaussian heat source where heat flow is controlled by tissue thermal properties and tissue perfusion. Temperature profiles were measured with thermocouples or calculated from magnetic resonance imaging in agreement with the model. A 2-s T1-weighted gradient-refocused acquisition provided thermal profiles needed to localize the heat distribution produced by a 4-s focused ultrasound pulse. Thermal analysis of the images give an effective thermal diffusion coefficient of 0.0015 cm2/s in gel and 0.0033 cm2/s in muscle. The lesions were detected using a T2-weighted spin-echo or fast spin-echo pulse sequence in agreement with muscle tissue sections. Potential thermal surgery applications are in the prostate, liver, kidney, bladder, breast, eye and brain.
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Citations
Elastographic characterization of HIFU-induced lesions in canine livers.
Raffaella Righetti,Raffaella Righetti,Faouzi Kallel,R. Jason Stafford,Roger E. Price,Thomas A. Krouskop,John D. Hazle,Jonathan Ophir +7 more
TL;DR: Elastography has the potential to become a reliable and accurate modality for HIFU therapy monitoring and a high correlation between the damaged areas as depicted by the elastograms and the corresponding areas as measured from the gross pathology photographs was found.
290
Focused US system for MR imaging-guided tumor ablation.
Harvey E. Cline,Kullervo Hynynen,Ronald Dean Watkins,W J Adams,John F. Schenck,Robert Helmut Ettinger,W R Freund,J P Vetro,Ferenc A. Jolesz +8 more
TL;DR: MR imaging provides target definition and control for thermal therapy in regions of variable perfusion or in tissues that are not well characterized in patients with tumor-guided tumor ablation.
284
Focused ultrasound surgery in oncology: overview and principles.
TL;DR: The background, principles, technical devices, and clinical cancer applications of image-guided FUS are reviewed.
Ultrasound technology for hyperthermia.
TL;DR: A general review of a selection of ultrasound hyperthermia systems that utilize a favorable range of energy penetration characteristics in soft tissue and the ability to shape the energy deposition patterns as a means to better localize and control HT for the aforementioned therapies.
241
Magnetic resonance temperature imaging
TL;DR: Real-time image processing and visualization techniques, together with accelerated MRI acquisition techniques, are described because of their potential for therapy guidance.
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