1. What are the contributions in "Mafld: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease" ?
The rest of authors declare no competing interests for this manuscript.
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2. What are the future works in "Mafld: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease" ?
Future studies will allow us to further characterise and sub-phenotype the disease and its drivers as a necessary prerequisite for the design of more appropriate clinical trials and for patient management and to consider the implications of the updated of nomenclature on clinical practice and public health policy ( Figure 4 ).
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3. What are the important genes that are being investigated for steatohepatitis?
some such as peroxisome proliferator-activated receptorPPARα, farnesoid X receptor (FXR) and liver X receptor (LXR), which are highly gender dependent, are currently being investigated as therapeutic targets for steatohepatitis 51.
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4. What is the main determinant of adverse outcomes of fatty liver disease?
As the authors know, there is tremendousplasticity in metabolic liver disease over the life span and strong evidence that fibrosis is the major determinant of adverse outcomes21.
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