Journal Article10.1038/NI.1937
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
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TL;DR: A better understanding of the molecular basis of myelomonocytic cell plasticity will open new vistas in immunopathology and therapeutic intervention and provide a paradigm for macrophage plasticity and function.
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Abstract: Plasticity is a hallmark of cells of the myelomonocytic lineage. In response to innate recognition or signals from lymphocyte subsets, mononuclear phagocytes undergo adaptive responses. Shaping of monocyte-macrophage function is an essential component of resistance to pathogens, tissue damage and repair. The orchestration of myelomonocytic cell function is a key element that links inflammation and cancer and provides a paradigm for macrophage plasticity and function. A better understanding of the molecular basis of myelomonocytic cell plasticity will open new vistas in immunopathology and therapeutic intervention.
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Direct and indirect regulation of the tumor immune microenvironment by VEGF
TL;DR: In this paper , the authors discuss the direct and indirect effects of VEGF on the immunosuppressive tumor microenvironment with particular focus on the direct regulation of immune cells through VEGFR2 activity.
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Role of infiltrating monocytes/macrophages in acute and chronic neuroinflammation: Effects on cognition, learning and affective behaviour.
TL;DR: Macrophage polarisation may be dictated by the inflammatory queues these cells are exposed to upon migration and their subsequent impact on neuronal function may be determined by their ability to resolve the underlying inflammation.
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Long-term intake of Lactobacillus paracasei KW3110 prevents age-related chronic inflammation and retinal cell loss in physiologically aged mice.
Yuji Morita,Kenta Jounai,Akihiko Sakamoto,Yasuyuki Tomita,Yoshihiko Sugihara,Hiroaki Suzuki,Konomi Ohshio,Masato Otake,Daisuke Fujiwara,Osamu Kanauchi,Mitsuo Maruyama +10 more
- 19 Oct 2018
TL;DR: Findings suggested that long-term intake of heat-killed L. paracasei KW3110 mitigated age-related chronic inflammation through modulation of gut microbiota composition and immune system functions in aged mice, and also reduced age- related retinal ganglion cell (RGC) loss.
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Evaluating the benefits of renin-angiotensin system inhibitors as cancer treatments.
TL;DR: Given that AngII-dependent AT1R activity directly regulates angiogenesis, remodeling of vasculature, pro-inflammatory responses, stem cell programming and hematopoiesis, and electrolyte balance; the modulation of these processes with pharmacologically well characterized medications could present a valuable complementary treatment option for cancer patients.
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Pro-tumor activities of macrophages in the progression of melanoma.
TL;DR: Based upon the information presented in this review, it is anticipated that new therapies will soon be developed that target pro-tumor activities of macrophages for use in the treatment of melanoma.
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TL;DR: Recent evidence suggests that differential modulation of the chemokine system integrates polarized macrophages in pathways of resistance to, or promotion of, microbial pathogens and tumors, or immunoregulation, tissue repair and remodeling.
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