Journal Article10.1038/NI.1937
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
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TL;DR: A better understanding of the molecular basis of myelomonocytic cell plasticity will open new vistas in immunopathology and therapeutic intervention and provide a paradigm for macrophage plasticity and function.
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Abstract: Plasticity is a hallmark of cells of the myelomonocytic lineage. In response to innate recognition or signals from lymphocyte subsets, mononuclear phagocytes undergo adaptive responses. Shaping of monocyte-macrophage function is an essential component of resistance to pathogens, tissue damage and repair. The orchestration of myelomonocytic cell function is a key element that links inflammation and cancer and provides a paradigm for macrophage plasticity and function. A better understanding of the molecular basis of myelomonocytic cell plasticity will open new vistas in immunopathology and therapeutic intervention.
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Citations
Tumor-associated macrophages as a prognostic parameter in multiple myeloma
Elif Suyanı,Gülsan Türköz Sucak,Nalân Akyürek,Sevinç Şahin,Nuran Ahu Baysal,Münci Yağcı,Rauf Haznedar +6 more
TL;DR: In conclusion, TAMs seems to be a promising prognostic histopathological marker in newly diagnosed MM patients and high-grade MVD was found to be associated with increased CD163+ cell count.
91
Diabetes during pregnancy influences Hofbauer cells, a subtype of placental macrophages, to acquire a pro-inflammatory phenotype.
Giorgia Sisino,Thomas Bouckenooghe,Sandra Aurientis,Pierre Fontaine,Laurent Storme,Anne Vambergue +5 more
TL;DR: It is demonstrated that diabetes/hyperglycemia affect the anti-inflammatory profile of HBCs, by stimulating these cells to acquire an inflammatory profile leading to adverse consequences for the fetal-placental-maternal axis.
91
Biomechanical factors and macrophages in plaque stability
TL;DR: How biomechanical factors modulate macrophage phenotype and plaque stability is explored, believed to promote conditions conducive to vulnerable plaque development.
FAK- and YAP/TAZ dependent mechanotransduction pathways are required for enhanced immunomodulatory properties of adipose-derived mesenchymal stem cells induced by aligned fibrous scaffolds.
TL;DR: Both FAK and YAP/TAZ signaling are identified as required mechanotransduction pathways through which aligned fibers stimulate the immunomodulatory function of ASCs and fiber orientation is highlighted as a key design parameter for immunommodulatory fibrous engineered scaffolds.
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Communications Between Bone Marrow Macrophages and Bone Cells in Bone Remodeling
Kaixuan Chen,Yurui Jiao,Ling Liu,Mei Huang,Chen He,Wenzhen He,Jing Hou,Mi Yang,Xiang-Hang Luo,Changjun Li +9 more
TL;DR: In this article, a review summarizes the current understanding of factors, exosomes, and hormones that involved in the communications between BMMs and other bone cells including mensenchymal stem cells, osteoblasts, osteocytes, and so on.
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Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
Jérôme Galon,Anne Costes,Fátima Sánchez-Cabo,Amos Kirilovsky,Bernhard Mlecnik,Christine Lagorce-Pagès,Marie Tosolini,Matthieu Camus,Anne Berger,Philippe Wind,Franck Zinzindohoué,Patrick Bruneval,Paul-Henri Cugnenc,Zlatko Trajanoski,Wolf H. Fridman,Franck Pagès +15 more
TL;DR: In situ analysis of tumor-infiltrating immune cells may be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies.
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Alberto Mantovani,Alberto Mantovani,Antonio Sica,Silvano Sozzani,Silvano Sozzani,Paola Allavena,Annunciata Vecchi,Massimo Locati +7 more
TL;DR: Recent evidence suggests that differential modulation of the chemokine system integrates polarized macrophages in pathways of resistance to, or promotion of, microbial pathogens and tumors, or immunoregulation, tissue repair and remodeling.
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