Book Chapter10.1007/978-1-59745-290-8_8
Machine-Learning Techniques
Rob Sullivan
- 01 Jan 2012
- pp 363-454
132
TL;DR: These two broad classifications of machine-learning methods will ground us as the authors discuss a broad range of techniques and where they are currently being applied in life sciences research, expanding their toolkit and enabling us to take a very different path in their analysis efforts.
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Abstract: Our ultimate objective in data mining is to identify any hidden patterns or relationships between our data elements, and in one sense, machine learning provides us with a set of techniques to do just that: techniques that allow us to learn the patterns without any outside influence (unsupervised learning). However, just as is the case with anything, that power comes at a price, but the results can be very interesting and very significant. In other cases, we have some sense on what the results should be and so can guide the learning techniques through an initial “training” phase, directing our system and honing the results (supervised learning). These two broad classifications of machine-learning methods will ground us as we discuss a broad range of techniques and where they are currently being applied in life sciences research, expanding our toolkit and enabling us to take a very different path in our analysis efforts: using an artificial intelligence discipline and letting the data tell us what it contains. As datasets grow, these techniques become more important.
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119
References
Machine learning in the life sciences
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Variations on the Boltzmann machine
G. Barna,Kimmo Kaski +1 more
TL;DR: Replacement of the Monte Carlo method in the Boltzmann machine by a direct formula promises faster evaluation without significant loss of precision.
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Comparison of SVM-Based Methods for Remote Homology Detection
TL;DR: The results of comparison of algorithms for remote homology detection using the SCOP database are shown and a new SVM based method (SVM-SW) is proposed, which uses the Smith-Waterman (SW) dynamic programming algorithm as a kernel function.
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•Dissertation
Gene expression analysis in breast cancer
Jai Prakash Mehta
- 01 Mar 2010
TL;DR: The role of Ropporin in cancer cell motility and invasion was validated and a Neural Network back propagation model was successful in predicting relapse with 97.8% accuracy and outperformed existing models, indicating a strong possibility of its use as diagnostic model.
9
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