Mace‐Like Plasmonic Au‐Pd Heterostructures Boost Near‐Infrared Photoimmunotherapy
Yanlin Feng,Xin Qiang Ning,Jianlin Wang,Zhaoyang Wen,Fangfang Cao,Qing You,Jianhua Zou,Xin Zhou,Teng Sun,Jimin Cao +9 more
TL;DR: In this article , a mace-like plasmonic AuPd heterostructures (Au Pd HSs) have been fabricated to boost near-infrared (NIR) photoimmunotherapy.
read more
Abstract: Photoimmunotherapy, with spatiotemporal precision and noninvasive property, has provided a novel targeted therapeutic strategy for highly malignant triple‐negative breast cancer (TNBC). However, their therapeutic effect is severely restricted by the insufficient generation of tumor antigens and the weak activation of immune response, which is caused by the limited tissue penetration of light and complex immunosuppressive microenvironment. To improve the outcomes, herein, mace‐like plasmonic AuPd heterostructures (Au Pd HSs) have been fabricated to boost near‐infrared (NIR) photoimmunotherapy. The plasmonic Au Pd HSs exhibit strong photothermal and photodynamic effects under NIR light irradiation, effectively triggering immunogenic cell death (ICD) to activate the immune response. Meanwhile, the spiky surface of Au Pd HSs can also stimulate the maturation of DCs to present these antigens, amplifying the immune response. Ultimately, combining with anti‐programmed death‐ligand 1 (α‐PD‐L1) will further reverse the immunosuppressive microenvironment and enhance the infiltration of cytotoxic T lymphocytes (CTLs), not only eradicating primary TNBC but also completely inhibiting mimetic metastatic TNBC. Overall, the current study opens a new path for the treatment of TNBC through immunotherapy by integrating nanotopology and plasmonic performance.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Photothermal Nanomaterials: A Powerful Light-to-Heat Converter
Ximin Cui,Qifeng Ruan,Xiaolu Zhuo,Xin Xia,Jingtian Hu,Runfang Fu,Yan Li,Jianfang Wang,Hongxing Xu +8 more
TL;DR: In this paper , the authors present an extensive catalogue of nanostructured photothermal materials, including metallic/semiconductor structures, carbon materials, organic polymers, and two-dimensional materials.
589
Janus Nanofiber Membranes with Photothermal‐Enhanced Biofluid Drainage and Sterilization for Diabetic Wounds
Xiaojing Zhang,Nuo Yu,Qian Ren,Shining Niu,Liqiong Zhu,Kangle Cui,Xiao Wang,Mei Wen,Zhigang Chen +8 more
TL;DR: The study has presented the design of a biomimetic asymmetric Janus membrane that integrates unidirectional biofluid drainage and photothermal‐enhanced evaporation/sterilization capabilities for accelerating diabetic wound healing.
47
Mace‐Like Plasmonic Au‐Pd Heterostructures Boost Near‐Infrared Photoimmunotherapy
Yanlin Feng,Xin Qiang Ning,Jianlin Wang,Zhaoyang Wen,Fangfang Cao,Qing You,Jianhua Zou,Xin Zhou,Teng Sun,Jimin Cao +9 more
TL;DR: In this article , a mace-like plasmonic AuPd heterostructures (Au Pd HSs) have been fabricated to boost near-infrared (NIR) photoimmunotherapy.
25
A mace-like heterostructural enriched injectable hydrogel composite for on-demand promotion of diabetic wound healing.
Li Wang,Zahid Hussain,Peng Zheng,Yajie Zhang,Yi Cao,Tong Gao,Zhuangzhuang Zhang,Yuehu Zhang,Renjun Pei +8 more
TL;DR: In this article , a multifunctional heterostructural nanoparticles enriched minimally invasive hydrogels for on-demand procedural distribution to aid wound healing at various stages has become a promising strategy.
20
Manipulating calcium homeostasis with nanoplatforms for enhanced cancer therapy
Yanlin Feng,Jianlin Wang,Jimin Cao,Fangfang Cao,Xiaoyuan Chen +4 more
TL;DR: In this review, the current nanoplatforms that regulate Ca2+ homeostasis for cancer therapy are discussed, including both direct and indirect approaches to manageCa2+ overload or inhibit Ca2+, and the applications of these nanoplplatforms in targeting different cells to regulate their Ca2-homeostasis are systematically introduced.
16
References
Adoptive immunotherapy for cancer: building on success.
TL;DR: How a lymphopaenic environment enables tumour-reactive T cells to destroy large burdens of metastatic tumour and how the state of differentiation of the adoptively transferred T cells can affect the outcome of treatment are described.
Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death.
Wei Li,Jie Yang,Lihua Luo,Mengshi Jiang,Bing Qin,Hang Yin,Chunqi Zhu,Xiaoling Yuan,Junlei Zhang,Zhenyu Luo,Yong-Zhong Du,Qingpo Li,Yan Lou,Yunqing Qiu,Jian You +14 more
TL;DR: ER-targeting PDT-PTT promoted ICD-associated immunotherapy through direct ROS-based ER stress and exhibited enhanced anti-tumour efficacy.
TNF-alpha in cancer treatment: molecular insights, antitumor effects, and clinical utility.
TL;DR: An overview of the use of TNF-alpha in cancer is provided starting with molecular insights into TNFR-1 signaling and cellular mechanisms of the antitumor activities of T NF-alpha and ending with clinical response.
756
Human t cell responses against melanoma
TL;DR: In patients who do respond to the vaccine, the antivaccine T cells probably succeed in reversing focally this immunosuppression and trigger a broad activation of other antitumor T cells, which proceed to destroy the tumor.
707
Plasmonic Harvesting of Light Energy for Suzuki Coupling Reactions
Feng Wang,Chuanhao Li,Chuanhao Li,Huanjun Chen,Ruibin Jiang,Ling-Dong Sun,Quan Li,Jianfang Wang,Jimmy C. Yu,Chun-Hua Yan +9 more
TL;DR: This work reports here on the direct harvesting of visible-to-near-infrared light for chemical reactions by use of plasmonic Au-Pd nanostructures, and compares the effect of joint plasMonic photocatalysis and photothermal conversion with that of sole Photothermal conversion.
622