Lymphotropic herpesviruses in allogeneic bone marrow transplantation
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TL;DR: The data indicate that HHV-6 variant B can inhibit marrow engraftment and that high-dose acyclovir prophylaxis may be beneficial toEngraftment after BMT by preventing HHv-6 reactivation.
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About: This article is published in Blood. The article was published on 01 Nov 1996. and is currently open access. The article focuses on the topics: Platelet Engraftment & Human cytomegalovirus.
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Citations
A rapid monitoring system of human herpesviruses reactivation by LightCycler in stem cell transplantation.
K Aritaki,Junko H. Ohyashiki,Junko H. Ohyashiki,Suzuki A,Tomoko Ojima,Kenji Abe,Norio Shimizu,Kohtaro Yamamoto,Kazuma Ohyashiki,Akinori Hoshika +9 more
TL;DR: The reactivation of β herpesviruses is associated with the occurrence of thrombotic microangiopathy (TMA) in two patients undergoing allogeneic BMT and may contribute in clarifying the pathological potential of human herpesvirus using a large number of clinical samples.
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Infections with human herpesvirus 6 variant B delay platelet engraftment after allogeneic haematopoietic stem cell transplantation
Aleksandar Radonić,Olivia Oswald,Stefanie Thulke,Nina Brockhaus,Andreas Nitsche,Wolfgang Siegert,Johannes Schetelig +6 more
TL;DR: Early infections with HHV‐6B may contribute to delayed platelet engraftment after allogeneic SCT, and the two variants of HHV-6 should be studied separately.
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Quantification of human herpesvirus 6 in healthy volunteers and patients with lymphoproliferative disorders by PCR-ELISA.
Junko H. Ohyashiki,Kenji Abe,Tomoko Ojima,Ping Wang,Chang Fang Zhou,Suzuki A,Kazuma Ohyashiki,Kohtaro Yamamoto +7 more
TL;DR: The results suggest that measurement of HHV-6 genomes using PCR-ELISA may be useful not only to understand the mechanism of HHv-6 infection in hemopoietic neoplasia but also to manage the care of immnocompromised patients such as bone marrow transplant patients.
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Diagnosis of Pulmonary Infections in Immunocompromised Patients by Fiber-optic Bronchoscopy with Bronchoalveolar Lavage and Serology
Britt-Marie Eriksson,Helena Dahl,Fu-Zhang Wang,Kerstin Elvin,Gunnar Hillerdal,Monica Lundholm,Annika Linde,Elisabeth Olding-Stenkvist +7 more
TL;DR: D diagnosis was achieved more often in renal transplant patients than in patients with hematological malignancies, and it was not possible to relate findings of coagulase-negative staphylococci, alpha-streptococci and Candida albicans to the pulmonary infection.
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References
Ganciclovir prophylaxis to prevent cytomegalovirus disease after allogeneic marrow transplant
James M. Goodrich,Raleigh A. Bowden,Lloyd D. Fisher,Claire Keller,Gary Schoch,Joel D. Meyers +5 more
TL;DR: A randomized placebo-controlled trial of ganciclovir given to CMV-seropositive allogeneic marrow transplant recipients at the time of engraftment and before CMV excretion or disease is performed, which shows an advantage of this prophylaxis strategy, compared with early treatment strategies.
695
Epstein-Barr virus associated B cell lymphoproliferative disorders following bone marrow transplantation.
R. S. Shapiro,Kenneth L. McClain,Glauco Frizzera,Kazimiera J. Gajl-Peczalska,J. H. Kersey,Bruce R. Blazar,Diane C. Arthur,Donna F. Patton,JS Greenberg,Barbara A. Burke +9 more
TL;DR: B cell lymphoproliferative disorders developed in eight patients following bone marrow transplantation for leukemia or immunodeficiency, and seven patients died despite aggressive attempts at therapy with combinations of antiviral, immunologic, and chemotherapeutic agents.
524
Fatal Encephalitis Due to Variant B Human Herpesvirus-6 Infection in a Bone Marrow-Transplant Recipient
TL;DR: Human herpesvirus-6 is the causative agent of exanthem subitum and febrile illnesses in children and has been implicated in interstitial pneumonitis, and bone marrow suppression after transplantation, and the pathogenicity of HHV-6 has yet to be fully delineated in either immunocompetent or Immunocompromised hosts.
347
Epstein-Barr virus DNA in cerebrospinal fluid from patients with AIDS-related primary lymphoma of the central nervous system
Paola Cinque,Maria Brytting,Britta Wahren,Annika Linde,Antonella Castagna,Adriano Lazzarin,Luca Vago,Carlo Parravicini,Nadia Zanchetta,A d'Arminio Monforte +9 more
TL;DR: PCR for EBV DNA in CSF was 100% sensitive and 98.5% specific for AIDS-associated primary CNS lymphoma, and may be useful as a diagnostic tumour marker.
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