Journal Article10.3233/JAD-2008-14208
Luteinizing hormone levels are positively correlated with plasma amyloid-β protein levels in elderly men
Giuseppe Verdile,Bu B. Yeap,Bu B. Yeap,R. Clarnette,R. Clarnette,R. Clarnette,Satvinder S. Dhaliwal,Melanie S. Burkhardt,Melanie S. Burkhardt,Melanie S. Burkhardt,S. A. Paul Chubb,Karl De Ruyck,Karl De Ruyck,Mark Rodrigues,Mark Rodrigues,Pankaj D. Mehta,Jonathan K. Foster,Jonathan K. Foster,David G. Bruce,David G. Bruce,Ralph N. Martins +20 more
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Citations
Alzheimer's Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies-Gains from AIBL and DIAN Cohort Studies
Ralph N. Martins,Victor L. Villemagne,Hamid R. Sohrabi,Pratishtha Chatterjee,Pratishtha Chatterjee,Tejal M. Shah,Tejal M. Shah,Giuseppe Verdile,Giuseppe Verdile,Paul E. Fraser,Kevin Taddei,Kevin Taddei,Veer Bala Gupta,Veer Bala Gupta,Stephanie R. Rainey-Smith,Eugene Hone,Eugene Hone,Steve Pedrini,Steve Pedrini,Wei Ling Lim,Ian Martins,Shaun Frost,Sunil Gupta,Sid E. O'Bryant,Alan Rembach,David Ames,Kathryn A. Ellis,Stephanie J. Fuller,Belinda M. Brown,Samantha L. Gardener,Binosha Fernando,Prashant Bharadwaj,Samantha C. Burnham,Samantha C. Burnham,Simon M. Laws,Simon M. Laws,Anna M. Barron,Anna M. Barron,Kathryn Goozee,Eka J. Wahjoepramono,Prita R. Asih,James D. Doecke,Olivier Salvado,Olivier Salvado,Ashley I. Bush,Ashley I. Bush,Christopher C. Rowe,Sam Gandy,Colin L. Masters +48 more
TL;DR: The journey from the discovery of the Aβ peptide in Alzheimer’s disease (AD) brain to the establishment of pre-clinical AD using PET amyloid tracers, a method now serving as the gold standard for developing peripheral diagnostic approaches in the blood and the eye is discussed.
Sex Differences and the Influence of Sex Hormones on Cognition through Adulthood and the Aging Process
TL;DR: The aim of the current paper was to provide a theoretical review of how sex hormones influence cognitive functioning across the lifespan as well as provide an overview of the literature on sex differences and the role of sex hormones in cognitive decline, specifically in relation to Alzheimer’s disease.
Down-regulation of serum gonadotropins is as effective as estrogen replacement at improving menopause-associated cognitive deficits.
Kathryn J. Bryan,Joseph C. Mudd,Sandy L. Richardson,Jaewon Chang,Hyoung Gon Lee,Xiongwei Zhu,Mark A. Smith,Gemma Casadesus +7 more
TL;DR: In this paper, the role of postmenopausal gonadotropin increases on cognition has been evaluated and it was shown that the down-regulation of ovariectomy-driven luteinizing hormone (LH) elevations using the releasing hormone super-analogue, leuprolide acetate, improves cognitive function in the Morris water maze and Y-maze tests in the absence of E2.
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The reproductive-cell cycle theory of aging: An update
Craig S. Atwood,Richard L. Bowen +1 more
TL;DR: The Reproductive-Cell Cycle Theory can explain aging in all sexually reproductive life forms and is able to explain why the authors develop aging-related diseases.
66
Higher luteinizing hormone is associated with poor memory recall: the health in men study.
Zoë Hyde,Leon Flicker,Osvaldo P. Almeida,Kieran McCaul,Konrad Jamrozik,Graeme J. Hankey,S. A. Paul Chubb,Bu B. Yeap +7 more
TL;DR: A role for both androgens and gonadotropins in differing cognitive domains is suggested, and that gonadotropic levels may influence cognition independent of sex steroids.
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Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
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A practical method for grading the cognitive state of patients for the clinician
Marshal Folstein,Susan E B Folstein,F. Folstein,Paul R. McHugh +3 more
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James E. Hixson,D. T. Vernier +1 more
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CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia.
TL;DR: A new interview schedule for the diagnosis and measurement of dementia in the elderly is described and is acceptable to patients, has a high inter-rater reliability and the cognitive section has been shown to have high and specificity.
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