Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients
Angèle P. M. Kerckhoffs,Melvin Samsom,Michel E. van der Rest,Joris de Vogel,Jan Knol,Kaouther Ben-Amor,Louis M. A. Akkermans +6 more
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TL;DR: In this paper, decreased bifidobacteria levels in both fecal and duodenal brush samples of IBS patients compared to healthy subjects indicate a role for microbiotic composition in IBS pathophysiology.
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Abstract: CONCLUSION: Decreased bifidobacteria levels in both fecal and duodenal brush samples of IBS patients compared to healthy subjects indicate a role for microbiotic composition in IBS pathophysiology.
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References
The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects.
Anna Kassinen,Lotta Krogius-Kurikka,Harri Mäkivuokko,Teemu Rinttilä,Lars Paulin,Jukka Corander,Erja Malinen,Juha Apajalahti,Airi Palva +8 more
TL;DR: The study showed that fecal microbiota is significantly altered in IBS, and further studies on molecular mechanisms underlying these alterations are needed to elucidate the exact role of intestinal bacteria in the syndrome.
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Mucosa-associated bacteria in the human gastrointestinal tract are uniformly distributed along the colon and differ from the community recovered from feces
Erwin G. Zoetendal,Terttu Vilpponen-Salmela,Kaouther Ben-Amor,Antoon D. L. Akkermans,Willem M. de Vos +4 more
TL;DR: The observed host-specific DGGE profiles of the mucosa-associated bacterial community in the colon support the hypothesis that host-related factors are involved in the determination of the GI tract microbial community.
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Effect of antimicrobial agents on the ecological balance of human microflora.
TL;DR: By using antimicrobial agents that do not disturb colonisation resistance, the risk of emergence and spread of resistant strains between patients and dissemination of resistant determinants between microorganisms is reduced.
864
Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome.
Peter J. Whorwell,Linda Altringer,Jorge G. Morel,Yvonne Bond,Duane Larry Charbonneau,Liam O'Mahony,Barry Kiely,Fergus Shanahan,Eamonn Martin Quigley +8 more
TL;DR: B. infantis 35624 at a dose of 1 × 108 cfu was significantly superior to placebo and all other bifidobacterium doses for the primary efficacy variable of abdominal pain as well as the composite score and scores for bloating, bowel dysfunction, incomplete evacuation, straining, and the passage of gas at the end of the 4-wk study.
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Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome
TL;DR: An improvement in irritable bowel syndrome symptoms with diarrhea and abdominal pain being statistically significant after Bonferroni correction is revealed.
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