Journal Article10.1016/J.RDC.2012.03.006
Low Vitamin D Status: Definition, Prevalence, Consequences, and Correction
TL;DR: It seems premature to recommend widespread screening for 25(OH)D measurement, but targeted measurement in those at increased risk for vitamin D deficiency and those most likely to have a prompt positive response to supplementation is appropriate.
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Abstract: Low vitamin D status is extremely common worldwide due to low dietary intake and low skin production. Suboptimal vitamin D status contributes to many conditions, including osteomalacia/rickets, osteoporosis, falls, and fractures. It is possible or even likely that low vitamin D status increases risk for a multitude of other conditions. Although consensus does not exist, it appears that circulating 25(OH)D concentrations greater than 30 to 32 ng/mL are needed for optimal health. To achieve this, daily intakes of at least 1000 IU of D3 daily are required, and it is probable that substantially higher amounts are required to achieve such values on a population basis. It seems premature to recommend widespread screening for 25(OH)D measurement. Targeted measurement in those at increased risk for vitamin D deficiency and those most likely to have a prompt positive response to supplementation is appropriate. Widespread optimization of vitamin D status likely will lead to prevention of many diseases with attendant reduction of morbidity, mortality, and expense.
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Citations
Hypovitaminosis D in migrant children in Switzerland: a retrospective study.
TL;DR: Three-quarters of migrant children evaluated at the migrant clinic in Geneva’s children hospital are deficient in vitamin D, one third severely and a strategy to correct the deficiency would be to supplement all migrant children at arrival and in winter.
Dosing Strategy of Vitamin D Therapy in Patients with Rheumatic Diseases in Bahrain
Adla Bakri Hassan,Ahmed Shaker Naga,Sarra Kamal Mustafa,Ahmed Abdel Karim Jaradat,Diab Eltayeb Diab,Haitham Ali Jahrami +5 more
TL;DR: This study assesses vitamin D status and dosing strategies in 158 Bahraini patients with rheumatic diseases, finding that parenteral vitamin D3 therapy significantly increases serum levels, with optimal maintenance achieved through oral doses of 50,000 IU every 24 weeks.
Cardiovascular Benefits of Vitamin D.
Jinghui Dong,Chi Wai Lau,Siu Ling Wong,Yu Huang +3 more
TL;DR: Emerging evidence suggests vitamin D deficiency is linked to cardiovascular and chronic kidney diseases, with benefits including protecting cardiac function, lowering blood pressure, and inhibiting oxidative stress through modulation of gene transcription via vitamin D receptors.
Anamnestic risk factor questionnaire as reliable diagnostic instrument for osteoporosis (reduced bone morphogenic density)
Leila Kolios,Caner Takur,Arash Moghaddam,Mirjam Hitzler,Heinrich Schmidt-Gayk,Arnold J. Suda,Bernd Höner,Paul Alfred Grützner,Christoph Wölfl +8 more
TL;DR: Anamnestic risk factors correlate with pathological BMD and the medical questionnaire used in this study would function as a cost-effective primary diagnostic instrument for identification of osteoporosis patients.
Vitamin D Awareness and Intake in Collegiate Athletes.
Bennett A. Leitch,Patrick B. Wilson,Kelsey Ufholz,James N. Roemmich,Joanna Orysiak,Tanis J. Walch,Sandra E. Short,John S. Fitzgerald +7 more
TL;DR: Results showed small-to-moderate, positive correlations between aspects of vitamin D awareness and vitamin D intake, particularly with supplemental forms ofitamin D.
References
Vitamin D Deficiency
TL;DR: The role of vitamin D in skeletal and nonskeletal health is considered and strategies for the prevention and treatment ofitamin D deficiency are suggested.
Clinician’s Guide to Prevention and Treatment of Osteoporosis
Felicia Cosman,S. J. de Beur,Meryl S. LeBoff,E. M. Lewiecki,B. Tanner,S. Randall,Robert Lindsay +6 more
TL;DR: The Clinician’s Guide to Prevention and Treatment of Osteoporosis was developed by an expert committee of the National Osteiporosis Foundation in collaboration with a multispecialty council of medical experts in the field of bone health convened by NOF.
Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
Philip T. Liu,Steffen Stenger,Huiying Li,Linda Wenzel,Belinda H. Tan,Stephan R. Krutzik,Maria Teresa Ochoa,Jürgen Schauber,Kent Wu,Christoph Meinken,Diane L. Kamen,Manfred Wagner,Robert Bals,Andreas Steinmeyer,Ulrich Zügel,Richard L. Gallo,David Eisenberg,Martin Hewison,Bruce W. Hollis,John S. Adams,Barry R. Bloom,Robert L. Modlin +21 more
TL;DR: The data support a link between TLRs and vitamin D–mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection.
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Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes
Heike A. Bischoff-Ferrari,Edward Giovannucci,Walter C. Willett,Thomas Dietrich,Bess Dawson-Hughes +4 more
TL;DR: Evidence from studies that evaluated thresholds for serum 25(OH)D concentrations in relation to bone mineral density, lower-extremity function, dental health, and risk of falls, fractures, and colorectal cancer suggests that an increase in the currently recommended intake of vitamin D is warranted.
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Overview of general physiologic features and functions of vitamin D
TL;DR: An overview of the physiologic, endocrinologic, and molecular biologic characteristics of vitamin D is provided and information on new selective analogs of 1alpha,25-dihydroyvitamin D3 for therapy is provided.
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