Journal Article10.1210/JCEM-54-4-808
Low Renin-Aldosterone in “Prehypertensive” Young Adults
Theodore A. Kotchen,Gordon P. Guthrie,Carol M. Cottrill,Harlley E. McKean,Jane Morley Kotchen +4 more
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TL;DR: Reinin suppression precedes the onset of hypertension and may be an appropriate response to higher levels of arterial pressure, and PRA was lower in black than in white subjects both before and after exercise.
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Abstract: PRA is suppressed in approximately 25% of patients with essential hypertension. To determine if renin suppression precedes the onset of hypertension, PRA and plasma aldosterone were measured before and after treadmill exercise in 129 young adults with relatively high, intermediate, or relatively low blood pressures sustained over 5 yr. PRA and aldosterone responses to exercise were lower (P < 0.01) in the high blood pressure group. In contrast, plasma renin substrate was lower (P < 0.01) in the low blood pressure group. Unrelated to blood pressure, PRA, but not aldosterone, was lower in black than in white subjects both before and after exercise. In conclusion, renin suppression precedes the onset of hypertension and may be an appropriate response to higher levels of arterial pressure.
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Citations
Liddle's Syndrome Revisited -- A Disorder of Sodium Reabsorption in the Distal Tubule
TL;DR: A woman with this syndrome is described, in whom renal failure eventually developed and who received a cadaveric renal transplant at the authors' institution in 1989, and whose disorder resolved after transplantation, with normalization of the aldosterone and renin responses to salt restriction.
335
Genetic Variants in the Epithelial Sodium Channel in Relation to Aldosterone and Potassium Excretion and Risk for Hypertension
Walter T. Ambrosius,Laura J. Bloem,Lifen Zhou,John F. Rebhun,P. M. Snyder,Mary Anne Wagner,Chunlu Guo,J H Pratt +7 more
TL;DR: Several lines of evidence are presented to suggest that ENaC activity is higher in blacks than in whites, which could contribute to racial differences in Na retention and the risk for hypertension.
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Are renal hemodynamics a key factor in the development and maintenance of arterial hypertension in humans
TL;DR: The regulation of renal blood flow appears to be a key element in the pathophysiology of the hypertensive process, because multiple evidence suggests the existence of a functional enhancement of renal vascular tone in this disorder.
102
Association of the Angiotensinogen Gene to Serum Angiotensinogen in Blacks and Whites
TL;DR: Using a haplotype to differentiate further the T235 carrier state, an association of genotype with serum angiotensinogen level and blood pressure in blacks and whites is observed and suggests that AGT may play an important role in blood pressure regulation in both racial groups.
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Association of renin and aldosterone with ethnicity and blood pressure: the Multi-Ethnic Study of Atherosclerosis.
Dena E. Rifkin,Ali Raza Khaki,Nancy S. Jenny,Robyn L. McClelland,Matthew J. Budoff,Karol E. Watson,Joachim H. Ix,Matthew A. Allison,Matthew A. Allison +8 more
TL;DR: Compared with whites, blacks have lower aldosterone and Hispanics have higher PRA and Aldosterone had significant associations with higher SBP in Hispanics compared with other groups, a finding that may suggest a different mechanism of hypertension.
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TL;DR: It is demonstrated that without profound sodium depletion, age may be more important than sodium excretion as a frame of reference for judging both renin and norepinephrine measurements; both factors should be considered for interpretation of PA.
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