Low plasma testosterone and elevated carotid intima-media thickness: importance of low-grade inflammation in elderly men.

TL;DR: Among men with androgen deficiency, dispensed testosterone prescriptions were associated with a lower risk of cardiovascular outcomes over a median follow-up of 3.4 years, compared with 3.7 years in the never-TRT group.

TL;DR: A general policy of testosterone replacement in all older men with age-related decline in testosterone levels is not justified, because the clinical benefits and long-term risks of testosterone therapy have not been adequately assessed in large, randomized clinical trials involving older men (defined as age>65 years) with androgen deficiency.

TL;DR: This article summarizes the current evidence regarding the relationship between testosterone (endogenous and supplemental) and CV health and selected publications within the past 10 years were selected.

TL;DR: In this article, the metabolic effects of testosterone replacement therapy (TRT) on hypogonadal men with type 2 diabetes mellitus (T2DM) were evaluated using a literature search performed using the Cochrane Library, EMBASE and PubMed.

TL;DR: In this article, an alternative approach, based on graphical techniques and simple calculations, is described, together with the relation between this analysis and the assessment of repeatability, which is often used in clinical comparison of a new measurement technique with an established one.

TL;DR: CRP concentration has continuous associations with the risk of coronary heart disease, ischaemic stroke, vascular mortality, and death from several cancers and lung disease that are each of broadly similar size.

TL;DR: The paradoxical finding that longitudinal age trends were steeper than cross-sectional trends suggests that incident poor health may accelerate the age-related decline in androgen levels.