Journal Article10.1080/17425247.2018.1450865
Low density, good flowability cyclodextrin-raffinose binary carrier for dry powder inhaler: anti-hygroscopicity and aerosolization performance enhancement.
Ziyu Zhao,Zhengwei Huang,Xuejuan Zhang,Ying Huang,Yingtong Cui,Cheng Ma,Guanlin Wang,Tim Freeman,Xiang-Yun Lu,Xin Pan,Chuanbin Wu +10 more
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TL;DR: CRBC with anti-hygroscopicity and aerosolization performance enhancement properties was a promising approach for pulmonary drug delivery, which could provide new possibilities to the application of hygroscopic carriers for DPI.
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Abstract: Background: The hygroscopicity of raffinose carrier for dry powder inhaler (DPI) was the main obstacle for its further application. Hygroscopicity-induced agglomeration would cause deterioration of aerosolization performance of raffinose, undermining the delivery efficiency.Methods: Cyclodextrin-raffinose binary carriers (CRBCs) were produced by spray-drying so as to surmount the above issue. Physicochemical attributes and formation mechanism of CRBCs were explored in detail. The flow property of CRBCs was examined by FT4 Powder Rheometer. Hygroscopicity of CRBCs was elucidated by dynamic vapor sorption study. Aerosolization performance was evaluated by in vitro deposition profile and in vivo pharmacokinetic profile of CRBC based DPI formulations.Results: The optimal formulation of CRBC (R4) was proven to possess anti-hygroscopicity and aerosolization performance enhancement properties. Concisely, the moisture uptake of R4 was c.a. 5% which was far lower than spray-dried raffinose (R0, c.a. 65%). ...
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Citations
Influence of Composition and Spray-Drying Process Parameters on Carrier-Free DPI Properties and Behaviors in the Lung: A review
Anna Lechanteur,Brigitte Evrard +1 more
TL;DR: A new type of carrier-free particles which are characterized by a sugar-based core encompassed by a corrugated shell layer produced by spray drying are focused on, which could help in the development of promising DPI systems suitable for local or systemic drug delivery.
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Innovative Drying Technologies for Biopharmaceuticals.
TL;DR: In this article, a review compiles some potential, innovative drying technologies that have not gained popularity for manufacturing parenteral biopharmaceuticals, such as Spin-freeze-drying, Spray-Drying, Lynfinity® Technology etc.
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Moisture-Resistant Co-Spray-Dried Netilmicin with l-Leucine as Dry Powder Inhalation for the Treatment of Respiratory Infections.
Yingtong Cui,Xuejuan Zhang,Xuejuan Zhang,Wang Wen,Zhengwei Huang,Ziyu Zhao,Guanlin Wang,Shihao Cai,Jing Hui,Ying Huang,Xin Pan,Chuanbin Wu +11 more
TL;DR: The additional LL in NTM DPI successfully reduced the hygroscopicity and improved the aerosolization performance, and NTM DPIs were proved to be a feasible and desirable approach for the treatment of LRTI.
A quantitative approach to predicting lung deposition profiles of pharmaceutical powder aerosols.
Shadi Yaqoubi,Hak-Kim Chan,Ali Nokhodchi,Siavoush Dastmalchi,Ali Akbar Alizadeh,Mohammad Barzegar-Jalali,Khosro Adibkia,Hamed Hamishehkar +7 more
TL;DR: A model was constructed to correlate the inhaler device properties, inhalation flow rate, particle characteristics and drug/excipient physico-chemical properties with the resultant fine particle fraction and believes that this model is capable of predicting the lung deposition pattern of a formulation with an acceptable precision.
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Hydroxypropyl beta cyclodextrin: a water-replacement agent or a surfactant upon spray freeze-drying of IgG with enhanced stability and aerosolization.
Shahriar Milani,Homa Faghihi,Abdolhosein Roulholamini Najafabadi,Mohsen Amini,Hamed Montazeri,Alireza Vatanara +5 more
TL;DR: The protective effect of HPβCD, as measured by size exclusion chromatography, was most pronounced at C3′ and C3″, IgG:trehalose:HPβCD ratios of 1:2:0.05, which are superior to the previous examination with regards to manifesting lower aggregation and comparable FPF values.
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