Looking for “fNIRS Signature” in Autism Spectrum: A Systematic Review Starting From Preschoolers
Eugenia Conti,Elena Scaffei,Chiara Bosetti,Viviana Marchi,Valeria Costanzo,Valerio Dell'Oste,R Mazziotti,Liliana Dell'Osso,Claudia Carmassi,Filippo Muratori,Laura Baroncelli,Sara Calderoni,Roberta Battini +12 more
TL;DR: Both functional connectivity in resting-state conditions and task-evoked brain activation using multiple experimental paradigms were used in the selected investigations, suggesting that fNIRS might be considered a promising method for identifying early quantitative biomarkers in the autism field.
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Abstract: Accumulating evidence suggests that functional Near-Infrared Spectroscopy (fNIRS) can provide an essential bridge between our current understanding of neural circuit organization and cortical activity in the developing brain. Indeed, fNIRS allows studying brain functions through the measurement of neurovascular coupling that links neural activity to subsequent changes in cerebral blood flow and hemoglobin oxygenation levels. While the literature offers a multitude of fNIRS applications to typical development, only recently this tool has been extended to the study of neurodevelopmental disorders (NDDs). The exponential rise of scientific publications on this topic during the last years reflects the interest to identify a “fNIRS signature” as a biomarker of high translational value to support both early clinical diagnosis and treatment outcome. The purpose of this systematic review is to describe the updating clinical applications of fNIRS in NDDs, with a specific focus on preschool population. Starting from this rationale, a systematic search was conducted for relevant studies in different scientific databases (Pubmed, Scopus, and Web of Science) resulting in 13 published articles. In these studies, fNIRS was applied in individuals with Autism Spectrum Disorder (ASD) or infants at high risk of developing ASD. Both functional connectivity in resting-state conditions and task-evoked brain activation using multiple experimental paradigms were used in the selected investigations, suggesting that fNIRS might be considered a promising method for identifying early quantitative biomarkers in the autism field.
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Interdisciplinary views of fNIRS: Current advancements, equity challenges, and an agenda for future needs of a diverse fNIRS research community
Emily Doherty,Cara A. Spencer,Jeremy D. Burnison,Marta Ceko,Jenna H. Chin,Lucca Eloy,Kerstin Sophie Haring,Pilyoung Kim,Daniel E. Pittman,Shannon Powers,Samuel L. Pugh,Demetris K. Roumis,J A Stephens,Tom Yeh,Leanne M. Hirshfield +14 more
TL;DR: In this article , a review of different research domains where functional near-infrared spectroscopy is utilized, identify and address the presence of bias, specifically due to the restraints of current fNIRS technology, limited diversity among sample populations, and the societal prejudice that infiltrates today's research.
What are quantitative traits and how can they be used in autism research?
TL;DR: There is growing interest in the use of quantitative traits in behavioral and psychiatric research, particularly in research on conditions diagnosed based on reports of behaviors, including autism as discussed by the authors , which can be used in autism research to help gain a better understanding of causal pathways and biological processes.
12
Using fNIRS to evaluate ADHD medication effects on neuronal activity: A systematic literature review
TL;DR: In this article, a systematic literature review was conducted for peer-reviewed articles related to ADHD, medication, and functional near infrared spectroscopy (fNIRS) in PsychInfo, Scopus, and PubMed electronic databases.
7
Atypical brain network development of infants at elevated likelihood for autism spectrum disorder during the first year of life
TL;DR: In this paper , the authors used a resting-state functional near-infrared spectroscopy (fNIRS) approach to obtain the length and strength of functional connections in the frontal and temporal areas in 45 5-month and 38 10-month infants.
Multimodal Investigation of Dynamic Brain Network Alterations in Autism spectrum disorder: Linking Connectivity Dynamics to Symptoms and Developmental Trajectories
Lin Wan,Yuhang Li,Gang Zhu,Dalin Yang,Fali Li,Sheng Wang,Jian Chen,Guang Yang,Rihui Li +8 more
TL;DR: This study investigates dynamic brain network alterations in autism spectrum disorder using EEG and fNIRS, linking connectivity dynamics to symptoms and developmental trajectories, and exploring associations with adaptive behavior in children with ASD.
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References
Diagnostic and Statistical Manual of Mental Disorders
Vijay A. Mittal,Elaine F. Walker +1 more
TL;DR: An issue concerning the criteria for tic disorders is highlighted, and how this might affect classification of dyskinesias in psychotic spectrum disorders.
Randomized, Controlled Trial of an Intervention for Toddlers With Autism: The Early Start Denver Model
Geraldine Dawson,Sally J. Rogers,Jeffrey Munson,Milani Smith,Jamie Winter,Jessica Greenson,Amy L. Donaldson,Jennifer A. Varley +7 more
TL;DR: This is the first randomized, controlled trial to demonstrate the efficacy of a comprehensive developmental behavioral intervention for toddlers with ASD for improving cognitive and adaptive behavior and reducing severity of ASD diagnosis.
Interpreting the BOLD signal.
TL;DR: The current understanding of the causal relationships between neural activity and the blood-oxygen-level-dependent (BOLD) signal is described, and how these analyses have challenged some basic assumptions that have guided neuroscience are reviewed.
1.7K
Non-invasive optical spectroscopy and imaging of human brain function
Arno Villringer,Britton Chance +1 more
TL;DR: First near-infrared imaging devices are being applied successfully for low-resolution functional brain imaging andvantages of the optical methods include biochemical specificity, a temporal resolution in the millisecond range, the potential of measuring intracellular and intravascular events simultaneously and the portability of the devices enabling bedside examinations.
1.7K
Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity
TL;DR: The findings suggest that the neural basis of disordered language in autism entails a lower degree of information integration and synchronization across the large-scale cortical network for language processing.
1.6K