Longitudinal relationships between disability and gait characteristics in people with MS
Sapir Dreyer-Alster,Shay Menascu,Mark Doyle,Uri Givon,David Magalashvili,Anat Achiron,Alon Kalron +6 more
TL;DR: In this article , the authors explored the relationship between changes in disability with changes in major spatio-temporal parameters of gait in people with multiple sclerosis (PwMS).
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Abstract: Abstract Longitudinal data are vital in order to understand intra individual gait changes with the progression of multiple sclerosis (MS). Therefore, the primary aim of this study was to explore the relationship between changes in disability with changes in major spatio-temporal parameters of gait in people with MS (PwMS). PwMS (n = 83) completed two gait assessments performed at separate time points (M1, M2). For each individual, the absolute difference between the Expanded Disability Status Scale (EDSS) score, key spatio-temporal parameters of gait, Falls Efficacy Scale International (FES-I), and the 12-item Multiple Sclerosis Walking Scale (MSWS-12), were calculated. The mean time difference between M1 and M2 was 2.5 (SD = 1.7) years. At M2, PwMS presented with shorter strides, a wider base of support, increased perceived mobility difficulties and fear of falling compared with M1. According to the odds ratio (OR) analysis, the odds of experiencing an increase in the EDSS score was significantly higher once the MSWS-12 score increased at M2 compared with M1 (OR = 7.930, p = 0.004). This observation was highlighted specifically in people with mild-moderate MS (OR = 12.427, p < 0.001). The increase in the EDSS score was not associated with changes in key spatio-temporal parameters of gait. The present study provides a better understanding of gait and disease progression in PwMS, highlighting the significant role of the MSWS-12.
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Citations
Uncovering Subtle Gait Deterioration in People with Early-Stage Multiple Sclerosis Using Inertial Sensors: A 2-Year Multicenter Longitudinal Study
Elisa Gervasoni,Denise Anastasi,Rachele Di Giovanni,Claudio Solaro,Marco Rovaris,Giampaolo Brichetto,Paolo Confalonieri,Andrea Tacchino,Ilaria Carpinella,Davide Cattaneo +9 more
- 01 Nov 2023
TL;DR: It is shown that instrumented assessment can detect subtle changes in gait stability, regularity, and symmetry not revealed during EDSS neurological assessment that impact on subjects’ perception of gait during activities of daily living.
5
Fear of Falling and Common Symptoms of Multiple Sclerosis: Physical Function, Cognition, Fatigue, Depression, and Sleep – A Systematic Review
Libak Abou,Joseph Peters,Bruno Freire,Jacob J. Sosnoff +3 more
TL;DR: This systematic review of 23 studies (2819 participants) finds significant correlations between fear of falling and multiple sclerosis symptoms, including walking deficits, cognitive impairments, fatigue, sleep disturbances, and depression, with bidirectional predictive relationships.
1
Innovative multidimensional gait evaluation using IMU in multiple sclerosis: introducing the semiogram
Cyril Voisard,Nicolas de l'Escalopier,Aliénor Vienne-Jumeau,Albane Moreau,Flavien Quijoux,Flavie Bompaire,Magali Sallansonnet,Marie-Laure Bréchemier,Irina Taifas,Camille Tafani,E. Drouard,Nicolas Vayatis,Damien Ricard,Laurent Oudre +13 more
TL;DR: The proposed multidimensional gait quantification represents an innovative approach to monitoring gait disorders and provides a reliable and informative biomarker for assessing the severity of gait impairments in individuals with pMS.
Does sensor-based gait assessment reflect self-perception of gait impairment in people with multiple sclerosis? A cross- sectional study
Sandra Schulthess,Eveline Graf,Bettina Sommer,Sandra Schulthess,Eveline Graf,Bettina Sommer +5 more
Abstract: Velocity remains a valuable metric, reflecting perceived walking impairments of people with MS. The findings to the association between the patient perceived walking impairments and the gait metrics mean double support time, swing time symmetry and swing time variability may highlight the relevance of balance-related metrics in assessing self-perceived walking impairments.
Fatigue in individuals with multiple sclerosis: is there a relationship with walking speed and mobility?
Vitória Eduarda Alves de Jesus,Raquel de Carvalho Lana,Manuela Ribeiro,Manuela Ribeiro,Raquel de Carvalho Lana,Manuela Ribeiro,Manuela Ribeiro,Raquel de Carvalho Lana +7 more
TL;DR: Fatigue in individuals with multiple sclerosis is related to walking speed and mobility limitations.
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