Journal Article10.1080/10543409708835204
Longitudinal analyses for magnetic resonance imaging outcomes in multiple sclerosis clinical trials.
Y D'yachkova,J Petkau,R White +2 more
12
TL;DR: The utility of the generalized estimating equations (GEE) approach to the analysis of longitudinal binary, count, and continuous responses for the frequent magnetic resonance imaging (MRI) substudy of the 3-year pivotal trial of interferon beta-1 b in relapsing-remitting multiple sclerosis is illustrated.
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Abstract: A basic feature of many clinical trials is the collection of longitudinal data on individual patients. Analysis of such data is often based on summaries over time. This allows use of standards methods to assess treatment effects but sacrifices information on patterns over time as well as potential greater efficiency of analysis. The purpose of this paper is to illustrate the utility of the generalized estimating equations (GEE) approach to the analysis of longitudinal binary, count, and continuous responses for the frequent magnetic resonance imaging (MRI) substudy of the 3-year pivotal trial of interferon beta-1 b in relapsing-remitting multiple sclerosis.
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Citations
A robust approach to t linear mixed models applied to multiple sclerosis data.
Tsung-I Lin,Jack C. Lee +1 more
TL;DR: A robust extension of linear mixed models based on the multivariate t distribution based on a parsimonious first-order autoregressive dependence structure for the within-subject errors is discussed and an explicit scoring procedure for the maximum likelihood estimation is developed.
Neutralizing antibodies during treatment of secondary progressive MS with interferon beta-1b.
TL;DR: The results support the conclusion that even though high NAB titers appear to have impact on treatment efficacy with respect to relapses, treatment decisions should be based primarily on clinical grounds.
References
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Random-effects models for longitudinal data
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Scott L. Zeger,Kung-Yee Liang +1 more
TL;DR: A class of generalized estimating equations (GEEs) for the regression parameters is proposed, extensions of those used in quasi-likelihood methods which have solutions which are consistent and asymptotically Gaussian even when the time dependence is misspecified as the authors often expect.
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Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial
D. W. Paty,David Kb Li +1 more
TL;DR: The MRI results demonstrate that IFNB has made a significant impact on the natural history of MS in these patients and support the clinical results in showing a significant reduction in disease activity as measured by numbers of active scans and appearance of new lesions.
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Nonlinear Mixed Effects Models for Repeated Measures Data
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