Journal Article10.3727/096368914X678526
Long-term survival and differentiation of human neural stem cells in nonhuman primate brain with no immunosuppression.
Sang-Rae Lee,Hong J. Lee,Sang-Hoon Cha,Kang Jin Jeong,Youngjeon Lee,Chang-Yeop Jeon,Kyung Sik Yi,Inja Lim,Zang-Hee Cho,Kyu-Tae Chang,Seung U. Kim,Seung U. Kim +11 more
TL;DR: Evidence is provided that hNSCs transplanted in NHP brain could survive and differentiate into neurons in the absence of immunosuppression and this study serves as a proof of principle and a preliminary study in scheduled preclinical studies of hN SC transplantation in N HP stroke models.
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About: This article is published in Cell Transplantation. The article was published on 01 Feb 2015. The article focuses on the topics: Transplantation & Neural stem cell.
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Citations
Immunosuppression for in vivo research: state-of-the-art protocols and experimental approaches
Rita Diehl,Fabienne Ferrara,Fabienne Ferrara,Claudia Müller,Antje Y. Dreyer,Damian D. McLeod,Stephan Fricke,Johannes Boltze,Johannes Boltze +8 more
TL;DR: This review summarizes current knowledge regarding immunosuppressive drug classes as well as their dosages and application regimens with consideration of species-specific drug metabolization and side effects and summarizes contemporary knowledge of novel immunomodulatory strategies, such as the use of mesenchymal stem cells or antibodies.
Cell Therapy for Parkinson's Disease: A Translational Approach to Assess the Role of Local and Systemic Immunosuppression.
R. Aron Badin,Marta Vadori,Bernard Vanhove,Bernard Vanhove,Véronique Nerrière-Daguin,Philippe Naveilhan,Isabelle Neveu,Caroline Jan,Xavier Lévêque,Eric Venturi,Pascal Mermillod,N. Van Camp,Frédéric Dollé,Martine Guillermier,Luca Denaro,Renzo Manara,Valentina Citton,Paolo Simioni,P. Zampieri,Domenico D'Avella,D. Rubello,F Fante,M Boldrin,G. M. De Benedictis,Laura Cavicchioli,Dino Sgarabotto,Mario Plebani,A Stefani,Philippe Brachet,Gilles Blancho,Gilles Blancho,J. P. Soulillou,Philippe Hantraye,Emanuele Cozzi +33 more
TL;DR: Results suggest that in this primate neurotransplantation model, peripheral immunosuppression is indispensable to achieve the long‐term survival of porcine neuronal xenografts that is required to study the beneficial immunomodulatory effect of local blockade of T cell costimulation.
34
An engineered neurovascular unit for modeling neuroinflammation.
Suyeong Seo,Chi Hoon Choi,Kyung Sik Lee,Seung U. Kim,Kangwon Lee,Nakwon Choi,Hong Jun Lee,Sang-Hoon Cha,Hong Nam Kim +8 more
TL;DR: In this paper, the authors present a 3D immortalized human cell-based neurovascular unit (NVU) model generated by organizing the brain microvasculature in a collagen matrix embedded with six different types of cells that comprise the NVU.
21
Non-human primate models of focal cortical ischemia for neuronal replacement therapy
Majumdar, Sayani,Cristóbal Kay +1 more
TL;DR: In this article , the authors review the recent progress of promising neuronal replacement therapy in NHP stroke studies and summarize the key characteristics of the NHP as highly valuable translational tools and discuss various methods for establishing NHP focal ischemic models to study the regenerative and plastic changes associated with motor functional recovery.
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Neural stem cell treatment for perinatal brain injury: A systematic review and meta-analysis of preclinical studies.
Madeleine J. Smith,Madeleine J. Smith,Madison C. B. Paton,Michael C Fahey,Graham Jenkin,Graham Jenkin,Suzanne L. Miller,Suzanne L. Miller,Megan Finch-Edmondson,Courtney McDonald +9 more
TL;DR: In this article, a systematic review was conducted to evaluate the preclinical literature to determine whether NSC administration is more effective than controls in decreasing perinatal brain injury in decreasing brain infarct size, motor and cognitive function.
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