Book Chapter10.1007/978-3-030-88832-9_143
Long-Term Potentiation
Bing Yan
- 01 Jan 2022
- pp 3053-3075
1
About: The article was published on 01 Jan 2022. The article focuses on the topics: Long-term potentiation & Metaplasticity.
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Endocrine disrupting effects on morphological synaptic plasticity
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TL;DR: This review examines the effects of endocrine disrupting chemicals (EDCs) on morphological synaptic plasticity, highlighting altered molecular mechanisms and emphasizing the need for further research on the impact of EDCs on neural regulation and homeostasis.
References
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
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Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
LTP and LTD: an embarrassment of riches.
Robert C. Malenka,Mark F. Bear +1 more
TL;DR: This work reviews those forms of LTP and LTD for which mechanisms have been most firmly established and examples are provided that show how these mechanisms can contribute to experience-dependent modifications of brain function.
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Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus.
TL;DR: Results indicate that the synaptic receptor in the Schaffer collateral‐commissural pathway may be of the kainate or quisqualate type and although NMA receptors do not appear to be involved in normal synaptic transmission in this pathway they may play a role in synaptic plasticity.
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Optogenetic stimulation of a hippocampal engram activates fear memory recall
Xu Liu,Steve Ramirez,Petti T. Pang,Corey B. Puryear,Arvind Govindarajan,Karl Deisseroth,Susumu Tonegawa +6 more
TL;DR: It is shown in mice that optogenetic reactivation of hippocampal neurons activated during fear conditioning is sufficient to induce freezing behaviour, and this findings indicate that activating a sparse but specific ensemble of hippocampusal neurons that contribute to a memory engram is sufficient for the recall of that memory.