Long-term dynamics of CA1 hippocampal place codes
Yaniv Ziv,Laurie D. Burns,Eric D. Cocker,Elizabeth Otto Hamel,Kunal K. Ghosh,Lacey J. Kitch,Abbas El Gamal,Mark J. Schnitzer,Mark J. Schnitzer +8 more
TL;DR: Using Ca2+ imaging in freely behaving mice that repeatedly explored a familiar environment, thousands of CA1 pyramidal cells' place fields over weeks were tracked to preserve an accurate spatial representation across weeks.
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Abstract: Using Ca(2+) imaging in freely behaving mice that repeatedly explored a familiar environment, we tracked thousands of CA1 pyramidal cells' place fields over weeks. Place coding was dynamic, as each day the ensemble representation of this environment involved a unique subset of cells. However, cells in the ∼15-25% overlap between any two of these subsets retained the same place fields, which sufficed to preserve an accurate spatial representation across weeks.
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The same hippocampal CA1 population simultaneously codes temporal information over multiple timescales
William Mau,David W. Sullivan,Nathaniel R. Kinsky,Michael E. Hasselmo,Marc W. Howard,Howard Eichenbaum +5 more
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