Long Noncoding RNA NHEG1 Drives β-Catenin Transactivation and Neuroblastoma Progression through Interacting with DDX5.
Xiang Zhao,Dan Li,Feng Yang,Heng Lian,Jianqun Wang,Xiaojing Wang,Erhu Fang,Huajie Song,Anpei Hu,Yanhua Guo,Yang Liu,Hongjun Li,Yajun Chen,Kai Huang,Liduan Zheng,Qiangsong Tong +15 more
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TL;DR: Results indicate that lncRNA NHEG1 exhibits oncogenic activity that affects NB progression via stabilizing the DDX5 protein, which might serve as a potential therapeutic target for NB.
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About: This article is published in Molecular Therapy. The article was published on 11 Jan 2020. and is currently open access. The article focuses on the topics: Tumor progression & Long non-coding RNA.
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Citations
DDX5 and DDX17—multifaceted proteins in the regulation of tumorigenesis and tumor progression
Kun Xu,Shenghui Sun,Mingjing Yan,Ju Cui,Yao Yang,Wen-Lin Li,Xiuqing Huang,Lin Dou,Beidong Chen,Weiqing Tang,Ming Lan,Jian Li,Tao Shen +12 more
TL;DR: The molecular structure features and biological functions of DDX5/DDX17 and their effects on tumorigenesis and tumor progression, as well as their potential clinical application for tumor treatment are discussed.
Noninvasive MRI Native T1 Mapping Detects Response to MYCN-targeted Therapies in the Th-MYCN Model of Neuroblastoma.
Konstantinos Zormpas-Petridis,Evon Poon,Matthew Clarke,Neil P. Jerome,Neil P. Jerome,Jessica K.R. Boult,Matthew D. Blackledge,Fernando Carceller,Fernando Carceller,Alexander Koers,Giuseppe Barone,Andrew D.J. Pearson,Lucas Moreno,John Anderson,John Anderson,Neil J. Sebire,Neil J. Sebire,Kieran McHugh,Dow-Mu Koh,Louis Chesler,Yinyin Yuan,Simon P. Robinson,Yann Jamin +22 more
TL;DR: Overall, the potential of T1 mapping, a scan readily available on most clinical MRI scanners, to assess response to therapy and guide clinical trials for children with neuroblastoma is demonstrated.
Emerging therapeutic targets for neuroblastoma.
TL;DR: Fittingly, the looming evidence indicated an aggressive evolution of promising novel and integrative targets, development of efficient drugs, and improvised strategies for HR-NB treatment.
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Action and function of helicases on RNA G-quadruplexes.
Marco Caterino,Katrin Paeschke +1 more
TL;DR: A review of the current knowledge on rG4s-processing helicases with a focus on methodological approaches is presented in this article, where an example of a non-helicase-unwinding protein is also briefly described.
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Comprehensive evaluation of differential long non-coding RNA and gene expression in patients with cartilaginous endplate degeneration of cervical vertebra.
Jinghong Yuan,Jingyu Jia,Tianlong Wu,Xijuan Liu,Shen Hu,Jian Zhang,Rui Ding,Chongzhi Pang,Xigao Cheng +8 more
TL;DR: The function of DEGs in the ceRNA network is analyzed and filtered out the same items as in DEG-function enrichment analysis, providing a new perspective for an improved understanding of ceRNA-mediated gene regulation in cervical spondylosis.
References
microRNA-9 Targets Matrix Metalloproteinase 14 to Inhibit Invasion, Metastasis, and Angiogenesis of Neuroblastoma Cells
TL;DR: It is indicated that miR-9 suppresses MMP-14 expression via the binding site in the 3′-UTR, thus inhibiting the invasion, metastasis, and angiogenesis of neuroblastoma.
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Overexpression and poly-ubiquitylation of the DEAD-box RNA helicase p68 in colorectal tumours
Mirsada Causevic,Mirsada Causevic,R. Gordon Hislop,Neil M. Kernohan,Francis A. Carey,Richard A. Kay,Robert Steele,Frances V. Fuller-Pace +7 more
TL;DR: The data indicate that p68 protein is consistently overexpressed in tumours as compared with matched normal tissue and that ubiquitylation of p68 occurs in cultured cells, thereby providing a model for the molecular analysis of this process and its potential role in tumorigenesis.
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High expression of ncRAN, a novel non-coding RNA mapped to chromosome 17q25.1, is associated with poor prognosis in neuroblastoma.
Meng Yu,Miki Ohira,Yuanyuan Li,Hidetaka Niizuma,Myat Lin Oo,Yuyan Zhu,Yuyan Zhu,Toshinori Ozaki,Eriko Isogai,Yohko Nakamura,Tadayuki Koda,Shigeyuki Oba,Bingzhi Yu,Akira Nakagawara +13 more
TL;DR: The results suggest that ncRAN may be a novel non-coding RNA mapped to the region of 17q gain and act like an oncogene in aggressive neuroblastomas.
Deregulated Wnt/beta-catenin program in high-risk neuroblastomas without MYCN amplification.
Xing Ge Liu,P Mazanek,V Dam,Qun Wang,Huizhen Zhao,Rong-Jun Guo,Jayanti Jagannathan,Avital Cnaan,John M. Maris,John M. Maris,Michael D. Hogarty,Michael D. Hogarty +11 more
TL;DR: High-risk NBs without MYCN amplification may deregulate MYC and other oncogenic genes via altered β-catenin signaling providing a potential candidate pathway for therapeutic inhibition.
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HPSE enhancer RNA promotes cancer progression through driving chromatin looping and regulating hnRNPU/p300/EGR1/HPSE axis.
Wanju Jiao,Yajun Chen,Huajie Song,Dan Li,Hong Mei,Feng Yang,Erhu Fang,Xiaojing Wang,Kai Huang,Liduan Zheng,Qiangsong Tong +10 more
TL;DR: Findings indicate that as a novel noncoding RNA, HPSE eRNA promotes cancer progression through driving chromatin looping and regulating hnRNPU/p300/EGR1/HPSE axis.
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