Localized blood flow imaging using quantitative flow-enhanced signal intensity
Cheng Ouyang,Bradley P. Sutton +1 more
TL;DR: A revised FENSI acquisition is proposed to enable quantitative imaging, which is capable of providing absolute localized blood flow maps free from magnetization transfer and slice profile errors, and validated by phantom studies.
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Abstract: Flow-enhanced signal intensity (FENSI) was previously introduced as a novel functional imaging method for measuring changes in localized blood flow in response to a stimulus. However, FENSI was limited to a qualitative functional MRI tool, due to magnetization transfer effects and different tagging plane profiles between tag and control images. In this work, a revised FENSI acquisition is proposed to enable quantitative imaging, which is capable of providing absolute localized blood flow maps free from magnetization transfer and slice profile errors. The feasibility and accuracy of measuring microvascular (arteriole, capillary, and venule) blood flow by using quantitative FENSI was validated by our phantom studies. Additionally, localized cerebral blood flow, 366 ± 45 μL/min/cm2 in gray matter and 153 ± 23 μL/min/cm2 in white matter, was measured in healthy subjects during resting state, whereas a flow change of 73 ± 13% was detected during a visual task. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.
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Citations
Optimizing pTILT perfusion imaging in the presence of off-resonance frequency.
TL;DR: To optimize the perfusion measurements and to recover loss of tagging efficiency from the blood flow measurements in the presence of static field inhomogeneity with the pseudo‐continuous arterial spin labeling technique of pTILT, which is sensitive to off‐resonance effects due to the employment of concatenated radiofrequency pulses for labeling.
1
Measuring CSF shunt flow with MRI using flow enhancement of signal intensity (FENSI).
Mingxiao Zhang,William C Olivero,Jason M Huston,Suguna Pappu,Paul M Arnold,Arundhati Biswas,Aaron T Anderson,Bradley P Sutton +7 more
TL;DR: A noninvasive MRI technique for measuring CSF shunt flow with flow enhancement of signal intensity (FENSI) is developed and validated. The technique accurately quantifies flow rates and has the potential for diagnosing and monitoring hydrocephalus.
1
Quantification of microvascular cerebral blood flux and late-stage tumor compartmentalization in 9L gliosarcoma using flow enhanced MRI.
TL;DR: This work characterize the evolution of the microvascular flux at different stages of tumor growth in the 9L rat brain tumor model, and observed a significant decrease in the cerebral blood flux inside the gliosarcoma.
1
•Dissertation
Development of FENSI (Flow Enhanced Signal Intensity) perfusion sequence and application to the characterization of microvascular flow dynamics using MRI
Olivier Reynaud
- 24 Sep 2012
TL;DR: This work focuses on the use of the recently introduced Flow Enhanced Signal Intensity method (FENSI) to characterize and quantify vasculature at capillary level, at high and ultra high magnetic field and the possible quantification of blood flux with FENSI is explored in vivo.
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