Journal Article10.1016/S1461-5347(98)00007-8
Liposomes: quo vadis?
Gert Storm,Daan J.A. Crommelin +1 more
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TL;DR: Liposomes have matured as a delivery system for therapeutic agents, and the authors provide their perspective on where the field is going and where opportunities can be found for rational improvement of drug therapy with liposomes.
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About: This article is published in Pharmaceutical Science & Technology Today. The article was published on 01 Apr 1998.
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Citations
LipHosomes: Reporters for Ligand/Anti-Ligand Assays Based On pH Readout
Martina Tripepi,Paolo O. Bennardi,Giuseppe Ferrauto,Silvio Aime,Daniela Delli Castelli +4 more
- 01 Feb 2021
TL;DR: A new class of liposomes (LipHosomes) designed to induce a change of pH upon releasing their content is reported about, which has an excellent sensitivity being able to reveal a concentration of bound LipHosome in the sub-pM range.
1
•Dissertation
Liposomes : a multifaceted delivery system
Sameer Joshi
- 23 Jun 2017
TL;DR: Here, for the first time, simultaneous co-encapsulation of hydrophilic and lipophilic drug was demonstrated, and microfluidics proved advantageous with regards to time required for liposome production, one-step production of small unilamellar vesicles (SUV), narrow PDI and effective drug encapsulation with lower amounts of lipids.
1
Desenvolvimento e caracterização de formulações lipossomais contendo o farmaco nistatina
Edeilza Gomes Brescansin,Francisco B. T. Pessine +1 more
- 20 Dec 2006
TL;DR: In this paper, aplicacoes of a formulacao lipossomal sistemica de nistatina (NYS) were investigated in vitro.
1
HPLC determination of encapsulated 5-fluorouracil in lyoiphilized liposomes
Irena Stojanovska,Suzana Trajkovic-Jolevska,Aneta Dimitrovska +2 more
- 01 Mar 2003
TL;DR: In this paper, a HPLC method for quantitative determination of encapsulated 5-fluorouracil in lyophilized liposomes was developed using the following chromatographic conditions: columnLiChrospher 60, RP Selected B, 125 x 4 mm, 5 μm; mobile phase 0.02 M phosphate buffer pH 4.7; flow rate of 1.0 ml/min; column temperature 20 oC; UV detection at 266 nm; injection volume 20 μl.
Design, Fabrication and Characterization of Nanoliposomes Containing Snake Venom of Pseudocereaster percius
Tara Emami,A Shirvan,Mahmoud Reza Jaafari,R. Madani,F. Golchinfar,N Mohammadpour Dounighi,Maedeh Samianifard +6 more
TL;DR: The findings revealed that dimethyldioctadecylamonium (Bromide salt) combined with cholesterol had the highest encapsulation efficiency, and in this formulation, the venom release rate had a steady-state profile.
References
Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors.
TL;DR: By selective changes in lipid composition, up to a 60-fold increase in the fraction of recovered dose present in blood 24 hr after i.v. injection is achieved, which has considerable therapeutic potential in cancer for increasing the concentration of cytotoxic agents in tumors while minimizing the likelihood of toxicity to the reticuloendothelial system.
Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system
TL;DR: The literature reviewed provides enough promise for anticipating therapeutic and diagnostic applications of surface-modified nanoparticles, with particular focus on the literature concerning particles other than liposomes.
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Specific targeting with poly(ethylene glycol)-modified liposomes: coupling of homing devices to the ends of the polymeric chains combines effective target binding with long circulation times
Gabriele Blume,Gregor Cevc,M.D.J.A. Crommelin,Irma A. J. M. Bakker-Woudenberg,C. Kluft,Gert Storm +5 more
TL;DR: It is shown that the PEG-modified liposomes with such a homing device coupled to the ends of the long PEG chains may combine long vesicle circulation times in the blood with high target binding capability.
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Liposomes as drug carriers : recent trends and progress
Gregory Gregoriadis
- 01 Jan 1988
TL;DR: This book is a substantial update and expansion of a previous volume edited by Gregoriadis and Allinson in 1980 and discusses applications related to antimicrobial and cancer therapy, vaccines, enzyme therapy, metal detoxification and diagnostics.
331
Liposomes in gene therapy
Danilo D. Lasic,N.S. Templeton +1 more
TL;DR: In this paper, DNA complexation with cationic polymers was used to coat DNA and then DNA recombination was performed to improve gene expression and to improve specific DNA sequences.
270