Journal Article10.1016/S1461-5347(98)00007-8
Liposomes: quo vadis?
Gert Storm,Daan J.A. Crommelin +1 more
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TL;DR: Liposomes have matured as a delivery system for therapeutic agents, and the authors provide their perspective on where the field is going and where opportunities can be found for rational improvement of drug therapy with liposomes.
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About: This article is published in Pharmaceutical Science & Technology Today. The article was published on 01 Apr 1998.
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Citations
•Journal Article
Binding of novel peptide inhibitors of type IV collagenases to phospholipid membranes and use in liposome targeting to tumor cells in vitro.
Oula Penate Medina,Tim Söderlund,Liisa J. Laakkonen,Esa K.J. Tuominen,Erkki Koivunen,Paavo K.J. Kinnunen +5 more
TL;DR: CTT enhanced 3- to 4-fold the cellular uptake of liposome-encapsulated water-soluble fluorescent marker, rhodamine B by gelatinase-expressing cells, and suggests a novel type of utility for small gelatinase inhibitors in targeted cancer therapy.
49
Recent Advances in Using Liposomes for Delivery of Nucleic Acid-Based Therapeutics
Hamdi Nsairat,Walhan Alshaer,Fadwa Odeh,Ezzaldeen Essawi,Dima Khater,Abeer Al Bawab,Mohamed El-Tanani,Abdalla Awidi,Mohammad S. Mubarak +8 more
TL;DR: A review of the literature that deals with liposomes in nucleic acid therapy is presented in this article , where the authors focus on the current advancements in nano-formulations, functionalization, and design and how it has been applied to nucleic acids therapeutics.
47
Liposomal systems as carriers for bioactive compounds.
Ana Maria Simao,Maytê Bolean,Thuanny Alexandra Campos Cury,Rodrigo G. Stábeli,Rosangela Itri,Pietro Ciancaglini +5 more
TL;DR: Liposomes are considered to be an invaluable asset in applied biotechnology studies due to their potential for interaction with both hydrophilic and lipophilic compounds.
Lipid composition-dependent incorporation of multiple membrane proteins into liposomes.
Katia Regina Perez Daghastanli,Rinaldo Bueno Ferreira,Geraldo Thedei,Bruno Maggio,Pietro Ciancaglini +4 more
TL;DR: Membrane proteins from bacteria Pasteurella multocida were used as a model for studying its incorporation into liposomes and the highest incorporation of multiple proteins was found with dipalmitoylphosphatidylcholine (DPPC), reaching a yield of 93% compared to the lower relative amounts incorporated in proteoliposomes of the other lipids.
43
Original Article: Diagnostic Nanomedicine An iodinated liposomal computed tomographic contrast agent prepared from a diiodophosphatidylcholine lipid
Don B. Elrod,Ranga Partha,Delia Danila,S. Ward Casscells,Jodie L. Conyers +4 more
- 01 Jan 2009
TL;DR: A novel vesicle-forming iodinated contrast agent for applications in computed tomographic (CT) imaging and drug delivery by chemically modified a phosphatidylcholine lipid to create an iodinated lipid that self-assembles into approximately 50-150 nm iodoliposomes possessing as-prepared imaging contrast functionality.
42
References
Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors.
TL;DR: By selective changes in lipid composition, up to a 60-fold increase in the fraction of recovered dose present in blood 24 hr after i.v. injection is achieved, which has considerable therapeutic potential in cancer for increasing the concentration of cytotoxic agents in tumors while minimizing the likelihood of toxicity to the reticuloendothelial system.
Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system
TL;DR: The literature reviewed provides enough promise for anticipating therapeutic and diagnostic applications of surface-modified nanoparticles, with particular focus on the literature concerning particles other than liposomes.
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Specific targeting with poly(ethylene glycol)-modified liposomes: coupling of homing devices to the ends of the polymeric chains combines effective target binding with long circulation times
Gabriele Blume,Gregor Cevc,M.D.J.A. Crommelin,Irma A. J. M. Bakker-Woudenberg,C. Kluft,Gert Storm +5 more
TL;DR: It is shown that the PEG-modified liposomes with such a homing device coupled to the ends of the long PEG chains may combine long vesicle circulation times in the blood with high target binding capability.
332
•Book
Liposomes as drug carriers : recent trends and progress
Gregory Gregoriadis
- 01 Jan 1988
TL;DR: This book is a substantial update and expansion of a previous volume edited by Gregoriadis and Allinson in 1980 and discusses applications related to antimicrobial and cancer therapy, vaccines, enzyme therapy, metal detoxification and diagnostics.
331
Liposomes in gene therapy
Danilo D. Lasic,N.S. Templeton +1 more
TL;DR: In this paper, DNA complexation with cationic polymers was used to coat DNA and then DNA recombination was performed to improve gene expression and to improve specific DNA sequences.
270