Book Chapter10.1007/978-3-642-36077-0_4
Liposomes for DNA Nanotechnology: Preparation, Properties, and Applications
Neeshma Dave,Juewen Liu +1 more
- 01 Jan 2013
- pp 57-76
5
TL;DR: This chapter describes methods for liposome preparation and DNA attachment, and discusses the biophysical properties of DNA-functionalized liposomes and their emerging applications in DNA-directed assembly, biosensor development, and drug delivery.
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Abstract: Over the past two decades, DNA has become a major player in nanotechnology. A very interesting and useful method uses DNA to link various nanoparticles, where the programmable structure and molecular recognition function of DNA are coupled to the optical, electric, magnetic, and catalytic property of the nanomaterials. Compared to many inorganic nanoparticles, liposomes are self-assembled soft matters that possess surface fluidity and the potential for molecular containment. The charge, size, and phase transition properties of liposomes can be precisely tuned by varying liposome formulation. In this chapter, we describe methods for liposome preparation and DNA attachment. We also discuss the biophysical properties of DNA-functionalized liposomes and their emerging applications in DNA-directed assembly, biosensor development, and drug delivery.
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Citations
DNA Hybridization-Mediated Liposome Fusion at the Aqueous Liquid Crystal Interface
TL;DR: A LC‐based approach for monitoring receptor (i.e., DNA hybridization)‐mediated liposome fusion is demonstrated, Liposome properties that dictate fusion dynamics are explored, and an example of how this approach may be used in a biosensing scheme is provided.
32
Photo-Responsivity of Azobenzene-Containing Glycolipid within Liquid-Gas Interface
Abstract: : Azobenzene-containing glycolipid, Gal-azo-Cn, was synthesized and its photoisomerization behavior within the liquid-gas interfaces was investigated by Langmuir Blodgett (LB) film measurements and atomic force microscopy. The results showed that Gal-azo-Cn could undergo trans-cis and cis-trans isomerization in both pure glycolipid and phospholipid-mixed films. UV-light induced isomerization increased the surface pressure. However, the membrane pressure within the liquid- gas interface could hinder the trans-cis isomerization. The high membrane pressure prevented the increase of surface pressure, weakening the trans-cis isomerization. In contrast, the cis-trans isomerization sped up in the dark. Compared with the isomerization behavior of pure glycolipid, the interaction between phospholipid and glycolipid could promote the trans-cis isomerization within the liquid-gas interface. In the mixed system, the increase in phospholipid containing unsaturated carbon chains increased the fluidity of the membrane but decreased its stability, which weaken the promotion effect of isomerization.
Non-spherical micro- and nanoparticles: fabrication, characterization and drug delivery applications
TL;DR: The latest developments in fabrication methods to tailor particle geometry are reported, analytical techniques for non-spherical particles are summarized and the most important findings regarding their interaction with biological systems and their potential applications in drug delivery are highlighted.
Photocontrollable Intermittent Release of Doxorubicin Hydrochloride from Liposomes Embedded by Azobenzene-Contained Glycolipid.
TL;DR: Results indicated that the synthesized GlyAzoCns could act as a role of smart actuators in the liposome bilayer and control the drug to release temporarily and quantitatively.
References
A DNA-based Method for Rationally Assembling Nanoparticles Into Macroscopic Materials
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Nathaniel L. Rosi,Chad A. Mirkin +1 more
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DNA in a material world
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