Journal Article10.1023/A:1010960900254
Liposomes bearing polyethyleneglycol-coupled transferrin with intracellular targeting property to the solid tumors in vivo
Osamu Ishida,Kazuo Maruyama,Hiroyuki Tanahashi,Motoharu Iwatsuru,Katsunori Sasaki,Masazumi Eriguchi,Hironobu Yanagie +6 more
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TL;DR: TF-PEG-liposomes had the capabilities of specific receptor binding and receptor-mediated endocytosis to target cells after extravasation into solid tumors in vivo.
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Abstract: Purpose. The purpose of this study was to determine the usefulness of transferrin (TF)-pendant-type polyethyleneglycol (PEG)-liposomes (TF-PEG-liposomes), in which TF was covalently linked to the distal terminal of PEG chains on the external surface of PEG-liposomes as a carrier for in vivo cytoplasmic targeting to tumor cells.
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