Lipid Nanoparticles for Drug Delivery

Abstract: Supplementary Material 7

TL;DR: A lipid nanoparticle-based dual-drug delivery system loaded with MCC 950 and disulfiram substantially improved the in vivo survival rate of mice for LPS-induced septic peritonitis and illustrated a significant reduction in the expression of active caspase-1 as well as IL-1β inhibition integral components in the NLRP3 pathway.

TL;DR: A truncated mini LRP1 variant transports cargo from the luminal to basolateral side across the blood-brain barrier, highlighting a novel mechanism for cargo transport across the barrier, with implications for drug delivery and neurological disorders.

TL;DR: An updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs and selective diagnosis through disease marker molecules is presented.

TL;DR: Advances in nanoparticle design that overcome heterogeneous barriers to delivery are discussed, arguing that intelligent nanoparticles design can improve efficacy in general delivery applications while enabling tailored designs for precision applications, thereby ultimately improving patient outcome overall.

TL;DR: This review summarizes historical and scientific perspectives of Doxil development and lessons learned from its development and 20 years of its use and demonstrates the obligatory need for applying an understanding of the cross talk between physicochemical, nano-technological, and biological principles.

TL;DR: In this paper, an attempt was made to elucidate the mechanisms of formation in terms of interfacial turbulence between two unequilibrated liquid phases involving flow, diffusion and surface tension decrease (Marangoni effect).