Lipid Nanoparticles for Drug Delivery

TL;DR: This review explores the use of nanoparticles as inhalable drug delivery vehicles for cystic fibrosis treatment, discussing material classes (metals, polymers, lipids) and their potential benefits, as well as FDA-approved nanoparticles for CF-related conditions.

TL;DR: Researchers developed a truncated mini LRP1 (mLRP1_DIV*) to transport cargo across the blood-brain barrier, demonstrating its ability to deliver therapeutic antibodies and immunoliposomes into the CNS and reduce toxic Aβ42 peptide levels in vitro.

TL;DR: This review synthesizes the current understanding of the application of nanomaterials or nano drug delivery systems on autophagy and their potential biological functions, suggesting a new avenue for nanomaterial-based autophagy regulation.

TL;DR: Biodistribution of therapeutic siRNAs delivered with lipid-substituted PEI-based delivery systems is improved in various organs, including xenograft tumors, with preferential accumulation in the lungs and spleen.

TL;DR: An updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs and selective diagnosis through disease marker molecules is presented.

TL;DR: Advances in nanoparticle design that overcome heterogeneous barriers to delivery are discussed, arguing that intelligent nanoparticles design can improve efficacy in general delivery applications while enabling tailored designs for precision applications, thereby ultimately improving patient outcome overall.

TL;DR: This review summarizes historical and scientific perspectives of Doxil development and lessons learned from its development and 20 years of its use and demonstrates the obligatory need for applying an understanding of the cross talk between physicochemical, nano-technological, and biological principles.

TL;DR: In this paper, an attempt was made to elucidate the mechanisms of formation in terms of interfacial turbulence between two unequilibrated liquid phases involving flow, diffusion and surface tension decrease (Marangoni effect).