Lipid Nanoparticles for Drug Delivery

TL;DR: Various proteins and peptides that are useful in ocular disorders, challenges in their delivery to the eye, and strategies to enhance ocular bioavailability using novel delivery approaches are highlighted.

TL;DR: A truncated mini LRP1 variant transports cargo from the luminal to basolateral side across the blood-brain barrier, highlighting a novel mechanism for cargo transport across the barrier, with implications for neurological disorders and drug delivery.

TL;DR: This review explores viral latency mechanisms and proposes nanocarrier-based interventions for targeted, efficient antiviral therapy, leveraging lipid-based, polymeric, and inorganic nanoparticles to combat persistent viral infections, including HIV, herpes, and HPV.

TL;DR: Synchrotron small-angle X-ray scattering reveals the internal structure of lipid nanoparticles, highlighting the presence of sticky patches and direct water-lipid interactions.

TL;DR: An updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs and selective diagnosis through disease marker molecules is presented.

TL;DR: Advances in nanoparticle design that overcome heterogeneous barriers to delivery are discussed, arguing that intelligent nanoparticles design can improve efficacy in general delivery applications while enabling tailored designs for precision applications, thereby ultimately improving patient outcome overall.

TL;DR: This review summarizes historical and scientific perspectives of Doxil development and lessons learned from its development and 20 years of its use and demonstrates the obligatory need for applying an understanding of the cross talk between physicochemical, nano-technological, and biological principles.

TL;DR: In this paper, an attempt was made to elucidate the mechanisms of formation in terms of interfacial turbulence between two unequilibrated liquid phases involving flow, diffusion and surface tension decrease (Marangoni effect).