Reference Entry10.1002/0470011815.B2A05068
Linkage Analysis, Multivariate
Mariza de Andrade,Christopher I. Amos +1 more
- 15 Jul 2005
TL;DR: An overview of multivariate linkage analysis methods can be found in this article, where the authors presented and discussed model-free multivariate methods that have been developed and used in linkage analysis.
read more
Abstract: This article provides an overview of the methodology currently available for multivariate linkage analysis. We presented and discussed model-free multivariate methods that have been developed and used in linkage analysis.
Keywords:
correlation;
trait;
variance components;
model-free multivariate methods
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
References
Empirical threshold values for quantitative trait mapping.
TL;DR: An empirical method is described, based on the concept of a permutation test, for estimating threshold values that are tailored to the experimental data at hand, and is demonstrated using two real data sets derived from F(2) and recombinant inbred plant populations.
Multipoint Quantitative-Trait Linkage Analysis in General Pedigrees
Laura Almasy,John Blangero +1 more
TL;DR: It is shown how variance-component linkage methods can be used in pedigrees of arbitrary size and complexity, and a general framework for multipoint identity-by-descent (IBD) probability calculations is developed.
Asymptotic Properties of Maximum Likelihood Estimators and Likelihood Ratio Tests under Nonstandard Conditions
Steven G. Self,Kung Yee Liang +1 more
TL;DR: In this article, the authors derived the asymptotic distribution of maximum likelihood estimators and likelihood ratio statistics, which is the same as the distribution of the projection of the Gaussian random variable.
2.7K
The investigation of linkage between a quantitative trait and a marker locus
J. K. Haseman,Robert C. Elston +1 more
TL;DR: Procedures are given, using sib pairs, for estimating linkage between a knownm-allele locus and a hypothesized two-alleel locus that governs a quantitative trait.
1.4K
Joint Multipoint Linkage Analysis of Multivariate Qualitative and Quantitative Traits. I. Likelihood Formulation and Simulation Results
TL;DR: A variance-components method for multipoint linkage analysis that allows joint consideration of a discrete trait and a correlated continuous biological marker in pedigrees of arbitrary size and complexity is described.
254
Related Papers (5)
Brian Everitt
- 15 Sep 2008
Michael Greatorex
- 21 Jan 2015
Chris Chatfield,Alexander J. Collins +1 more
- 01 Jan 1980