Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma.
TL;DR: This review focuses on the latest targeted delivery systems for HCC and summarizes the ligands that can enhance the capacity of active targeting, to provide some insight into future research in nanomedicine for H CC.
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Abstract: Hepatocellular carcinoma (HCC) is the most common primary liver cancer with high morbidity and mortality worldwide Chemotherapy is recommended to patients with intermediate or advanced stage cancer However, the conventional chemotherapy yields low desired response rates due to multidrug resistance, fast clearance rate, nonspecific delivery, severe side effects, low drug concentration in cancer cells, and so on Nanoparticle-mediated targeted drug delivery system can surmount the aforementioned obstacles through enhanced permeability and retention effect and active targeting as a novel approach of therapeutics for HCC in recent years The active targeting is triggered by ligands on the delivery system, which recognize with and internalize into hepatoma cells with high specificity and efficiency This review focuses on the latest targeted delivery systems for HCC and summarizes the ligands that can enhance the capacity of active targeting, to provide some insight into future research in nanomedicine for HCC
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References
CD147 monoclonal antibody mediated by chitosan nanoparticles loaded with α-hederin enhances antineoplastic activity and cellular uptake in liver cancer cells
Rong Zhu,Chun-ge Zhang,Yang Liu,Zhi-qiang Yuan,Wei-liang Chen,Shu-di Yang,Ji-zhao Li,Wen-jing Zhu,Xiao-feng Zhou,Ben-gang You,Xue-nong Zhang +10 more
TL;DR: The higher targeting antitumor efficacy of α-Hed-CS-CD147-NPs was attributed to its stronger fluorescence intensity in the tumor site in nude mice, and was related to CD147-mediated internalization through the Caveolae-dependent pathway and lysosomal escape.
Expression of somatostatin receptors in normal and cirrhotic human liver and in hepatocellular carcinoma
Hendrik Reynaert,Krista Rombouts,Alain Vandermonde,Daniel Urbain,Ujendra Kumar,Paulette Bioulac-Sage,Massimo Pinzani,Jean Rosenbaum,Albert Geerts +8 more
TL;DR: Although the somatostatin analogues used in this study did not affect proliferation and apoptosis, stimulation of SSTR1 may decrease invasiveness of HCC by reducing migration of hepatoma cells and/or HSCs.
Polymeric conjugates of mono- and bi-cyclic αvβ3 binding peptides for tumor targeting
TL;DR: The polymer conjugates of RGD4C or RGDfK provide a means to enhance tumor uptake, decrease background accumulation, and enable selective delivery of therapeutic or diagnostic agents to tumor sites.
Development of human hepatocellular carcinoma cell-targeted protein cages.
Riki Toita,Masaharu Murata,Shigekazu Tabata,Kana Abe,Sayoko Narahara,Jing Shu Piao,Jeong Hun Kang,Makoto Hashizume +7 more
TL;DR: A human hepatocellular carcinoma cell-targeted protein cage for which the HCC-binding peptide termed SP94 was modified at the surface of a naturally occurred heat shock protein (Hsp) cage was described.
Peptide-conjugated PAMAM for targeted doxorubicin delivery to transferrin receptor overexpressed tumors.
TL;DR: Evidence is provided that PAMAM-PEG-T7 can be applied as a potential tumor-targeting drug delivery system and in vitro antitumor effect was enhanced markedly and T7 may be a promising ligand for targeted drug delivery to the tumor.