Life at the Leading Edge
TL;DR: Four distinct protrusion methods likely act in concert to move cells through complex environments in vivo and require the coordination of a wide spectrum of signaling molecules and regulators of cytoskeletal dynamics.
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About: This article is published in Cell. The article was published on 24 Jun 2011. and is currently open access. The article focuses on the topics: Cortical actin cytoskeleton & Lamellipodium.
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Citations
Calcium-Calmodulin-Dependent Protein Kinase II Isoforms Differentially Impact the Dynamics and Structure of the Actin Cytoskeleton
TL;DR: Diversity exists between the types of Ca MKII-actin interactions mediated by the different isoforms and that the CaMKII isoform composition differentially impacts the formation and maintenance of the actin cytoskeleton, according to which the β isoform induces a novel layered structure in filaments.
Functions of cofilin in cell locomotion and invasion
Jose Javier Bravo-Cordero,Marco A. O. Magalhaes,Marco A. O. Magalhaes,Robert J. Eddy,Louis Hodgson,John S. Condeelis +5 more
TL;DR: These results have been integrated with recently discovered mechanisms for cofilin activation in migrating cells, which led to new models for coFilin function that provide insights into how co Filin regulation determines the temporal and spatial control of cell behaviour.
Functional and Therapeutic Relevance of Rho GTPases in Innate Immune Cell Migration and Function during Inflammation: An In Silico Perspective.
TL;DR: In this article, the activation and inactivation of Rho GTPases and the functioning of different Guanine Nucleotide Exchange Factors (GEFs) and GTPase-Activating Proteins (GAPs) are discussed.
Membrane Tension Orchestrates Rear Retraction in Matrix Directed Cell Migration
Joseph H. R. Hetmanski,Henry De Belly,Roshna V. Nair,Vanesa Sokleva,Oana Dobre,Angus J.M. Cameron,Nils Gauthier,Christophe Lamaze,Joe Swift,Aránzazu del Campo,Ewa K. Paluch,Jean-Marc Schwartz,Patrick T. Caswell +12 more
TL;DR: In this article, the authors reveal a mechanism of rear retraction in 3D matrix and durotaxis controlled by caveolae, which form in response to low membrane tension at the cell rear.
CHRFAM7A diversifies human immune adaption through Ca2+ signalling and actin cytoskeleton reorganization.
Kinga Szigeti,I. Ihnatovych,Emily Notari,Ryu P Dorn,Ivan Maly,Muye He,Barbara Birkaya,Shreyas Prasad,Robin Schwartz Byrne,Dinesh C Indurthi,Erik Nimmer,Yuna Heo,Kolos Retfalvi,Lee Chaves,Norbert Sule,Wilma A Hofmann,Anthony Auerbach,Gregory Wilding,Yongho Bae,Jessica Reynolds +19 more
TL;DR: CHRFAM7A introduces an additional, human specific, layer to Ca2+ regulation leading to an innate immune gain of function through the actin cytoskeleton it drives adaptation to the mechanical properties of the tissue environment leading to an ability to invade previously immune restricted niches.
References
Cell migration: integrating signals from front to back.
Anne J. Ridley,Martin A. Schwartz,Keith Burridge,Richard A. Firtel,Mark H. Ginsberg,Gary G. Borisy,J. Thomas Parsons,Alan Rick Horwitz +7 more
TL;DR: The mechanisms underlying the major steps of migration and the signaling pathways that regulate them are described, and recent advances investigating the nature of polarity in migrating cells and the pathways that establish it are outlined.
Cellular Motility Driven by Assembly and Disassembly of Actin Filaments
Thomas D. Pollard,Gary G. Borisy +1 more
TL;DR: A core set of proteins including actin, Arp2/3 complex, profilin, capping protein, and ADF/cofilin can reconstitute the process in vitro, and mathematical models of the constituent reactions predict the rate of motion.
4K
Collective cell migration in morphogenesis, regeneration and cancer
Peter Friedl,Darren Gilmour +1 more
TL;DR: Comparing different types of collective migration at the molecular and cellular level reveals a common mechanistic theme between developmental and cancer research.
The interaction of Arp2/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of filaments
TL;DR: It is shown that Arp2/3 complex purified from Acanthamoeba caps the pointed ends of actin filaments with high affinity and increases the critical concentration for polymerization at the pointed end from 0.6 to 1.0 microM.
1.5K
Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia.
T.M. Svitkina,Gary G. Borisy +1 more
TL;DR: The leading edge of lamellipodia in Xenopus laevis keratocytes and fibroblasts was shown to have an extensively branched organization of actin filaments, which is supported by a dendritic brush, suggesting that ADF/cofilin, per se, is not sufficient for actin brush depolymerization and a regulatory step is required.