Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins

TL;DR: Vascular endothelial cells and leukocytes express several inflammatory adhesion receptors, such as selectins and cell adhesion molecules, after retinal ischemia, which contribute to leukocyte rolling and adhesion.

TL;DR: The deformability and interactions of blood cells play a significant role in microcirculatory dynamics and modern biological approaches have provided insights into the molecular bases of blood cell deformable and interactions.

TL;DR: In this article, the authors present a two-dimensional neutrophil-rolling model to investigate whether and how membrane tethers contribute to stable neutrophin rolling. But their model assumes that neutrophils are rigid spheres covered with randomly distributed deformable microvilli, and endothelial cells are modeled as flat membrane surfaces decorated with evenly distributed ligands.

TL;DR: A polymeric NP system that interacts with an endothelial tumor marker is developed that may help NPs reach tumors by increasing the encounter of NPs with the peritumoral endothelium without hindering subsequent transport of the NPs.

TL;DR: Endothelial leukocyte adhesion molecule-1 (ELAM-1), a cell surface glycoprotein expressed by cytokine-activated endothelium, mediates the adhesion of blood neutrophils and may be a member of a nascent gene family of cell surface molecules involved in the regulation of inflammatory and immunological events at the interface of vessel wall and blood.

TL;DR: The purified ICAM-1 was incorporated into artificial supported lipid membranes and required metabolic energy production, an intact cytoskeleton, and the presence of Mg2+ and was temperature dependent, characteristics of LFA-1- and ICAM -1-dependent cell-cell adhesion.

TL;DR: Using bipolar co-ordinates, an exact solution of Stokes equations was obtained for the translational and rotational velocities of a neutrally buoyant sphere moving in proximity to a single plane wall under the influence of a simple shearing flow as mentioned in this paper.

TL;DR: Results in this report indicate that unstimulated neutrophils exhibit LFA-1-dependent attachment to ICAM-1, and chemotactic stimulation enhances the attachment of human neutrophil to IC AM-1 by a Mac-2-dependent process.