Journal Article10.1016/0092-8674(91)90393-D
Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins
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TL;DR: Rolling of leukocytes on vascular endothelial cells, an early event in inflammation, can be reproduced in vitro on artificial lipid bilayers containing purified CD62, a selectin also named PADGEM and GMP-140 that is inducible on endothelial Cells.
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About: This article is published in Cell. The article was published on 31 May 1991. The article focuses on the topics: Selectin & Cell adhesion.
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Citations
Effects of periocular administration of triamcinolone acetonide on leukocyte-endothelium interactions in the ischemic retina.
TL;DR: It is demonstrated that the periocular injection of TA effectively decreased retinal thickness and inhibited leukocyte-endothelium interactions in the retina after ischemia, suggesting downregulation of adhesion molecules of retinal vascular endothelium induced by TA may play a role in the course.
41
Beta2-integrins mediate stable adhesion in collisional interactions between neutrophils and ICAM-1-expressing cells.
Eric B. Lynam,Larry A. Sklar,A.D. Taylor,Sriram Neelamegham,Bruce S. Edwards,C. W. Smith,Scott I. Simon +6 more
TL;DR: Application of defined shear in a cone and plate viscometer showed that adhesion to the ICAM‐1 cells decreased from a maximum level to baseline as shear rate increased up to 400 s‐1 in a manner typical of integrin adhesion alone, in contrast, homotypic aggregation supported by the transition from selectin to integrin binding exhibited an increase in efficiency up to 800 s-1.
41
Cell receptor and surface ligand density effects on dynamic states of adhering circulating tumor cells.
TL;DR: Dynamic states of cancer cells moving under shear flow in an antibody-functionalized microchannel are investigated experimentally and theoretically and the characteristic flow rate increases monotonically with increasing either cell-receptor or surface-ligand density within certain ranges.
The role of the vascular endothelium in inflammatory syndromes, atherogenesis, and the propagation of disease
TL;DR: The importance of increased adhesive molecule expression on the endothelial surface in promoting circulating inflammatory cell-endothelial adherence in inflammatory conditions, as well as the role of the vascular endothelium in reperfusion injury, altered microvascular permeability states, and atherogenesis are discussed.
41
The immunology of respiratory allergies
TL;DR: Allergic airway inflammation and clinical asthma appear to be common histological and clinical consequences of a variety of specific and non-specific insults to the airways epithelium, airways mast cells and airways T lymphocytes.
41
References
Adhesion receptors of the immune system.
TL;DR: Three families of cell-surface molecules regulate the migration of lymphocytes and the interactions of activated cells during immune responses.
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Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins
TL;DR: Endothelial leukocyte adhesion molecule-1 (ELAM-1), a cell surface glycoprotein expressed by cytokine-activated endothelium, mediates the adhesion of blood neutrophils and may be a member of a nascent gene family of cell surface molecules involved in the regulation of inflammatory and immunological events at the interface of vessel wall and blood.
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Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1)
TL;DR: The purified ICAM-1 was incorporated into artificial supported lipid membranes and required metabolic energy production, an intact cytoskeleton, and the presence of Mg2+ and was temperature dependent, characteristics of LFA-1- and ICAM -1-dependent cell-cell adhesion.
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Slow viscous motion of a sphere parallel to a plane wall—II Couette flow
TL;DR: Using bipolar co-ordinates, an exact solution of Stokes equations was obtained for the translational and rotational velocities of a neutrally buoyant sphere moving in proximity to a single plane wall under the influence of a simple shearing flow as mentioned in this paper.
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Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro.
TL;DR: Results in this report indicate that unstimulated neutrophils exhibit LFA-1-dependent attachment to ICAM-1, and chemotactic stimulation enhances the attachment of human neutrophil to IC AM-1 by a Mac-2-dependent process.