Journal Article10.1016/0092-8674(91)90393-D
Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins
2.3K
TL;DR: Rolling of leukocytes on vascular endothelial cells, an early event in inflammation, can be reproduced in vitro on artificial lipid bilayers containing purified CD62, a selectin also named PADGEM and GMP-140 that is inducible on endothelial Cells.
read more
About: This article is published in Cell. The article was published on 31 May 1991. The article focuses on the topics: Selectin & Cell adhesion.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
A common theme in endothelial activation Insights from the structural analysis of the genes for E-selectin and VCAM-1.
TL;DR: Activation of the pleiotropic mediator NF-κB in endothelial cells could coordinate the expression of numerous endothelial products that are important in endothelium activation, including some cell surface adhesion proteins, cytokines, growth factors, and components of the coagulation system.
47
Neutrophil adhesion molecules intermandpremature infants: normalor enhanced leucocyte integrins butdefective L-selectin expression andshedding
N. Rebuck,A. Gibson,A. Finn +2 more
- 01 Jan 1995
TL;DR: It is proposed that the adhesive function of neonatal neutrophils may be less defective than previously thought and the isolation procedures used in previous reports reduces the capability of the cells to respond to a formyl methionine leucine phenylalanine stimulus.
47
Sialyl Lewis X mimetics attenuate E-selectin-mediated adhesion of leukocytes to irradiated human endothelial cells.
TL;DR: Radiation-mediated expression of E-selectin was dependent on dose and time and occurred at doses as low as 0.5 Gy, which implicate a new class of anti-inflammatory agents in the prevention of adhesions of leukocytes to the irradiated vascular endothelium.
47
New Concepts in the Immunology of Sickle Cell Disease
TL;DR: Anti-inflammatory medications, anti-adhesion molecule monoclonal antibodies, and adhesion molecule binding-site analogs may have a future in the treatment of the acute vascular complications of sickle cell disease.
47
New concepts in the immunology of sickle cell
M Moore,Mohammad Ehlayel,Lily E. Leiva,Ricardo U. Sorensen +3 more
- 01 Jan 1996
TL;DR: In this paper, the role of adhesion molecules, cytokines, and inflammation in the abnormal adherence of sickle red blood cells to vascular endothelia in the pathogenesis of vascular complication in patients with sickle cell anemia was reviewed.
47
References
Adhesion receptors of the immune system.
TL;DR: Three families of cell-surface molecules regulate the migration of lymphocytes and the interactions of activated cells during immune responses.
6.9K
Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins
TL;DR: Endothelial leukocyte adhesion molecule-1 (ELAM-1), a cell surface glycoprotein expressed by cytokine-activated endothelium, mediates the adhesion of blood neutrophils and may be a member of a nascent gene family of cell surface molecules involved in the regulation of inflammatory and immunological events at the interface of vessel wall and blood.
2.2K
Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1)
TL;DR: The purified ICAM-1 was incorporated into artificial supported lipid membranes and required metabolic energy production, an intact cytoskeleton, and the presence of Mg2+ and was temperature dependent, characteristics of LFA-1- and ICAM -1-dependent cell-cell adhesion.
1.8K
Slow viscous motion of a sphere parallel to a plane wall—II Couette flow
TL;DR: Using bipolar co-ordinates, an exact solution of Stokes equations was obtained for the translational and rotational velocities of a neutrally buoyant sphere moving in proximity to a single plane wall under the influence of a simple shearing flow as mentioned in this paper.
1.1K
Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro.
TL;DR: Results in this report indicate that unstimulated neutrophils exhibit LFA-1-dependent attachment to ICAM-1, and chemotactic stimulation enhances the attachment of human neutrophil to IC AM-1 by a Mac-2-dependent process.