Journal Article10.3166/dea-2022-0230
Les peptides RFamide et leurs récepteurs dans la modulation de la douleur
TL;DR: In this paper , a revue résume les connaissances sur la localisation of ces neuropeptides and de leurs récepteurs ainsi que leur rôle dans la modulation de la douleur.
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Abstract: Les peptides RFamide ont une extrémité carboxyterminale Arg-Phe-NH2 conservée et indispensable à leur activité. Ils sont impliqués dans la modulation de divers mécanismes biologiques, dont la douleur. Cette revue résume les connaissances sur la localisation de ces neuropeptides et de leurs récepteurs ainsi que leur rôle dans la modulation de la douleur. Les stratégies et outils thérapeutiques innovants en développement pour étudier le rôle respectif de ces récepteurs sont abordés.
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References
Anti-allodynic effects of intrathecally and intracerebroventricularly administered 26RFa, an intrinsic agonist for GRP103, in the rat partial sciatic nerve ligation model.
TL;DR: Data suggest that exogenously applied 26RFa modulates nociceptive transmission at the spinal and the supraspinal brain in the neuropathic pain model, and the mechanism 26 RFa uses to produce an anti-allodynic effect may be mediated by the activation of GPR103.
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The distribution of kisspeptin and its receptor GPR54 in rat dorsal root ganglion and up-regulation of its expression after CFA injection.
TL;DR: Interestingly, a marked elevation in the levels of KiSS-1 and GPR54 mRNA as well as protein was observed in the spinal dorsal horn and DRG 4 and 14 days following intra-articular injection of complete Freund's adjuvant (CFA), indicating a possible involvement of the kisspeptin/GPR54 system in chronic inflammatory pain.
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Intracerebroventricular Neuropeptide FF Diminishes the Number of Apneas and Cardiovascular Effects Produced by Opioid Receptors' Activation.
TL;DR: In this article, the authors examined the potency of neuropeptide FF to block post-opioid respiratory depression, one of the main adverse effects of opioid therapy and found that centrally administered NPFF is effective in preventing apnea evoked by stimulation of μ-OPioid receptors and the effect was due to activation of central NPFF receptors.
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Kisspeptin modulates pain sensitivity of CFLP mice
Krisztina Csabafi,Zsolt Bagosi,Éva Dobó,Júlia Szakács,Gyula Telegdy,Gyula Telegdy,Gyula Szabó +6 more
TL;DR: KP‐13 treatment depressed the acute antinociceptive effect of morphine and attenuated the development of morphine tolerance, and the results suggest that central KP‐13 administration can modify the acute effects of morphine.
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Microinjection of 26RFa, an endogenous ligand for the glutamine RF-amide peptide receptor (QRFP receptor), into the rostral ventromedial medulla (RVM), locus coelureus (LC), and periaqueductal grey (PAG) produces an analgesic effect in rats.
TL;DR: The hypothesis that the analgesic effects of 26RFa in the formalin test are mediated in well‐recognized regions of the descending inhibitory pain pathways, such as the rostral ventromedial medulla (RVM), locus coeruleus (LC), and periaqueductal grey (PAG) in rats is tested.
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