Learning and memory
TL;DR: A key regulator of synaptic plasticity is a signaling pathway that includes the mitogen activated protein (MAP) kinase, which is required for normal memory and learning, and it is not surprising that mutations in members of this pathway lead to disruptions in learning.
read more
About: This article is published in Revista Brasileira de Psiquiatria. The article was published on 01 Sep 2004. and is currently open access.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
A review on alcohol: from the central action mechanism to chemical dependency
João Victor Vezali Costardi,Rafael Augusto Teruaki Nampo,Gabriella Lourenço Silva,Maria Aparecida Ferreira Ribeiro,Heryck José Stella,Mercia Breda Stella,Sônia Valéria Pinheiro Malheiros +6 more
TL;DR: Knowledge on the neuronal signaling pathways that are altered by alcohol allows the identification of effectors which could reduce its central action, thus, offering new therapeutic perspectives for the rehabilitation of alcohol addicts.
Relação da memória visual com o desempenho ortográfico de crianças de 2ª e 3ª séries do ensino fundamental
Patricia Manfrin Fontes Barbosa,Neide Guzmán Blanco Bernardes,Mari Ivone Lanfredi Misorelli,Ana Lúcia de Magalhães Leal Chiappetta +3 more
TL;DR: In this article, the orthographic performance of children's handwriting from 2nd and 3rd years of elementary school was analyzed using the Rey Complex Figure 1.2.1 and it was found that children who made more orthographic mistakes during dictation, have worse performance on the Rey complex figure.
Effect of antox on hippocampal structure in male albino rats exposed to lead toxicity: histological and biochemical study
TL;DR: The present study showed a considerable ameliorating effect of antox on the structure of the hippocampus subjected to subclinical lead exposure, which eased the toxic effects of lead for all histological results.
8
•Journal Article
Oficina de educação, memória, esquecimento e jogos lúdicos para a terceira idade
Cecília Souza Oliveira,Sylvio Rogério Ribeiro da Costa,Ingrid Cristina Lúcio dos Santos,Carlos Eugênio Soares de Lemos +3 more
TL;DR: The taller de educacion for juegos que tienen como desempeno de la memoria, decir no al olvido and grantizar diversion for los ancianos, is un trabajo de extension que tiene como objetivo motivar la funcion cognitiva de la tercera edad and the posibilidad de ampliar sus redes de interaccion social.
Efeitos de um processo de alfabetização em informática na cognição de idosos
Natália Nunes Scoralick-Lempke,Altemir José Gonçalves Barbosa,Márcia Maria Peruzzi Elia da Mota +2 more
TL;DR: In this article, a hipotese de que a processo de alfabetizacao digital melhora as capacidades cognitivas de idosos, mais especificamente as memorias episodica e de trabalho, a meta-memoria and a autoeficacia em memoria, was tested.
References
Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP
Fred Petrif,Rachel H. Giles,Hans G. Dauwerse,Jasper J. Saris,Raoul C.M. Hennekam,Mitsuo Masuno,Niels Tommerup,Gert-Jan B. van Ommen,Richard H. Goodman,Dorien J.M. Peters,Martijn H. Breuning +10 more
TL;DR: It is proposed that the loss of one functional copy of the CBP gene underlies the developmental abnormalities in RTS and possibly the propensity for malignancy.
1.2K
Cross Talk between ERK and PKA Is Required for Ca2+ Stimulation of CREB-Dependent Transcription and ERK Nuclear Translocation
Soren Impey,Karl Obrietan,Scott T. Wong,Steve Poser,Shigetoshi Yano,Gary A. Wayman,Jean-Christophe Deloulme,Guy C.-K. Chan,Daniel R. Storm +8 more
TL;DR: It is reported that extracellular signal-related protein kinase (ERK) signaling is obligatory for Ca2+-stimulated transcription in PC12 cells and hippocampal neurons and suggests that the activation of CREB by ERK plays a critical role in the formation of long lasting neuronal plasticity.
920
Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1
Rui M. Costa,Nikolai B. Federov,Jeff H. Kogan,Geoffrey G. Murphy,Joel N. H. Stern,Masuo Ohno,Raju Kucherlapati,Tyler Jacks,Alcino J. Silva +8 more
TL;DR: The results indicate that the learning deficits associated with NF1 may be caused by excessive Ras activity, which leads to impairments in long-term potentiation caused by increased GABA-mediated inhibition.
622
The Mitogen-Activated Protein Kinase Cascade Couples PKA and PKC to cAMP Response Element Binding Protein Phosphorylation in Area CA1 of Hippocampus
Erik D. Roberson,Joey D. English,J. Paige Adams,Joel C. Selcher,Christine Kondratick,J. David Sweatt +5 more
TL;DR: An unexpected richness of diversity in the regulation of MAPK in the hippocampus is observed and the possibility of a broad role for the MAPK cascade in regulating gene expression in long-term forms of hippocampal synaptic plasticity is suggested.
558
Is the Ras-MAPK signalling pathway necessary for long-term memory formation?
TL;DR: The results obtained from these different systems demonstrate the involvement of Ras-dependent signalling in neuronal plasticity and behaviour and raise a number of intriguing questions.
203