Journal Article10.1186/s43066-023-00306-3
Latest advances in hepatocellular carcinoma management and prevention through advanced technologies
T. Addissouky,Ibrahim El Tantawy El Sayed,Majeed M. A. Ali,Yuliang Wang,Ayman El Baz,Ahmed A. Khalil,Naglaa Elarabany +6 more
TL;DR: Recent advances in early detection, management, and prevention of HCC have shown promise in improving patient outcomes, and AI and machine learning have greatly enhanced HCC research and management, while lifestyle modifications can play a critical role in prevention.
read more
Abstract: Abstract Background Hepatocellular carcinoma (HCC) is a common type of liver cancer, with a high mortality rate. Hepatocellular carcinoma is a type of liver cancer that can be effectively managed through early detection and accurate diagnosis, followed by a personalized treatment plan that may include surgical resection, liver transplantation, minimally-invasive techniques, immunotherapy, or targeted therapy depending on the stage and severity of the cancer. Main body of the abstract This paper discusses recent advances in the early detection, management, and prevention of HCC. The use of newer imaging techniques, such as Magnetic resonance imaging (MRI) and contrast-enhanced ultrasound, along with image segmentation technology and deep learning models, have greatly enhanced the accuracy of HCC detection and diagnosis. Minimally-invasive techniques, such as thermal ablation and radiofrequency ablation, have allowed for more precise and targeted destruction of tumors, while Nanoparticles, immunotherapy and targeted therapy have shown promise in the management of advanced stage HCC. The use of Artificial intelligence (AI) and machine learning has revolutionized HCC research, aiding in the identification of high-risk patients and predicting outcomes. Lifestyle modifications, such as weight management, alcohol avoidance, and hepatitis B vaccinations, can play a critical role in preventing HCC development. Short conclusion Recent advances in early detection, management, and prevention of HCC have shown promise in improving patient outcomes. The use of newer imaging techniques, minimally-invasive techniques, immunotherapy, targeted therapy, and AI and machine learning have greatly enhanced HCC research and management, while lifestyle modifications can play a critical role in prevention. However, further research is required to fully understand the potential benefits of nanoparticles, traditional Chinese medicine and herbal medicines in HCC treatment. Graphical Abstract
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Figures
![Fig. 3 Advancements in the integration of modern medicine and traditional Chinese medicine for the treatment of hepatocellular carcinoma have been made [107]](/figures/figure3-1-4p70si2y31pg.png)
Fig. 3 Advancements in the integration of modern medicine and traditional Chinese medicine for the treatment of hepatocellular carcinoma have been made [107] ![Fig. 2 illustrates a conceptual diagram of how AI can be used to diagnose HCC [64]](/figures/figure2-1-2xbwmp4g2lsq.png)
Fig. 2 illustrates a conceptual diagram of how AI can be used to diagnose HCC [64] 
Table 1 key advances in hepatocellular carcinoma ![Fig. 1 In this context, the utilization of liquid biopsy in the clinical management of patients suffering from hepatocellular carcinoma is discussed [57]](/figures/figure1-1-r9p98ttty0ta.png)
Fig. 1 In this context, the utilization of liquid biopsy in the clinical management of patients suffering from hepatocellular carcinoma is discussed [57]
Citations
Oxidative stress and inflammation: elucidating mechanisms of smoking-attributable pathology for therapeutic targeting
T. Addissouky,Ibrahim El Tantawy El Sayed,Majeed M. A. Ali,Ayman El Baz,Naglaa Elarabany,Ahmed A. Khalil +5 more
- 22 Jan 2024
TL;DR: This review aims to synthesize current scientific knowledge on mechanisms of smoking-induced disease, epidemiological trends, and clinical strategies from recent literature to suggest smoking cessation is critical to reducing preventable death and disability.
Translational Insights into Molecular Mechanisms of Chemical Hepatocarcinogenesis for Improved Human Risk Assessment
T. Addissouky
TL;DR: This study examines molecular mechanisms of chemical hepatocarcinogenesis in rodents and humans, highlighting interspecies differences in pathways like PPARα and CAR/PXR activation, to inform human risk assessment and regulatory decision-making for potential chemical hazards.
11
Biomarker discovery in hepatocellular carcinoma (HCC) for personalized treatment and enhanced prognosis
Baofa Yu,Wenxue Ma +1 more
TL;DR: Researchers identify key biomarkers (AFP, GPC3, DCP) and emerging technologies (NGS, mass spectrometry, liquid biopsies) to improve HCC diagnosis, treatment, and prognosis, but challenges persist in validation, standardization, and integration into clinical practice.
10
Type 1 diabetes mellitus: retrospect and prospect
T. Addissouky,Majeed M. A. Ali,Ibrahim El Tantawy El Sayed,Yuliang Wang +3 more
TL;DR: While type 1 diabetes remains challenging, ongoing research provides hope as innovative and multi-targeted therapies may fundamentally change the trajectory of T1D.
Schisandra chinensis in Liver Disease: Exploring the Mechanisms and Therapeutic Promise of an Ancient Chinese Botanical
T. Addissouky,Ibrahim El Tantawy El Sayed,Majeed M. A. Ali,Mahmood Hasen shuhata Alubiady,Yuliang Wang +4 more
TL;DR: Schisandra chinensis exhibits promising hepatoprotective effects in preclinical and small human studies, modulating inflammation, oxidative stress, and metabolic pathways. Further research is warranted to explore its therapeutic potential in various liver diseases.
6
References
Bacillus cereus foodborne illness--an update
TL;DR: A review of Bacillus cereus gastroenteritis, toxins, sources, survival, growth characteristics, enumeration, and prevention can be found in this article, where two distinct forms of Gastroenteritis and mastitis are reported.
7.2K
AASLD practice guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma
TL;DR: Singal, Amit G. as discussed by the authors , Llovet, Josep M.M.Marrero, Jorge A.Singal and Taddei, Tamar H.Taddei.
560
Changing epidemiology, global trends and implications for outcomes of NAFLD.
TL;DR: In this paper , the authors discuss recent changes in the epidemiology of NAFLD and NASH from regional and global perspectives, as well as in special populations, and discuss the potential consequences of these changes on hepatic and extrahepatic events.
236
Chitosan-Based Nanoparticles as Effective Drug Delivery Systems—A review
Karolina Jafernik,Agata Ładniak,Eliza Blicharska,Katarzyna Czarnek,Halina Ekiert,Agnieszka Ewa Wiącek,Agnieszka Szopa +6 more
TL;DR: In this paper , an overview has been made of the most frequently used preparation methods, and the developed applications in medicine, especially chitosan's properties in drug delivery systems (DDS), as well as the method of NPs production.
139
Application of carbon nanotubes in sensing/monitoring of pancreas and liver cancer.
TL;DR: In this paper , the role of carbon nanotubes (CNTs) in pancreatic and liver cancer theranostics is summarized and discussed, and the most feasible tactics utilizing CNT-based solutions for both cancer diagnosis and treatment are presented from the biomedical point of view.
124